{"id":14843,"date":"2022-03-17T10:21:29","date_gmt":"2022-03-17T10:21:29","guid":{"rendered":"https:\/\/solongevitypro.com\/longevity-news\/polydatin-and-coronavirus-what-the-studies-say\/"},"modified":"2022-12-14T08:44:17","modified_gmt":"2022-12-14T08:44:17","slug":"polydatin-and-coronavirus-what-the-studies-say","status":"publish","type":"post","link":"https:\/\/solongevity.com\/en\/longevity-news\/polydatin-and-coronavirus-what-the-studies-say\/","title":{"rendered":"Polydatin and Coronavirus, What the Studies Say"},"content":{"rendered":"<h3>A \u201cbio-mask?\u201d<\/h3>\n<p>It appears to sandwich itself between\u00a0<strong>coronavirus<\/strong>\u00a0spike proteins and\u00a0<strong>ACE-2 receptors<\/strong>\u00a0on human cells, thereby reducing the chances of infection. This is why\u00a0<strong>polydatin<\/strong>, a molecule already known and used in several<strong>\u00a0dietary supplements<\/strong>\u00a0for its\u00a0<strong>anti-inflammatory<\/strong>\u00a0and\u00a0<strong>antioxidant<\/strong>\u00a0actions, has been dubbed the \u201cbiological mask.\u201d But what is polydatin and how useful can it really be to us?<\/p>\n<h3>Polydatin, a valuable ally<\/h3>\n<p>Polydatin is a\u00a0<strong>natural<\/strong>\u00a0molecule that belongs to the\u00a0<strong>polyphenol<\/strong>\u00a0family. It can also be taken through\u00a0<strong>food<\/strong>\u00a0(it is present in grapes and peanuts, for example), but because of its properties it has become a basic ingredient in many\u00a0<strong>supplements<\/strong>. Polydatin is considered the precursor of\u00a0<strong>resveratrol<\/strong>, another natural molecule that improves the functioning of\u00a0<strong>mitochondria<\/strong>\u00a0(the power plants of cells) by modulating the action of sirtuins, the proteins encoded by \u201clongevity genes.\u201d<\/p>\n<blockquote><p>Its antioxidant and anti-inflammatory properties have earned polydatin the nickname \u201cthe biological mask\u201d<\/p><\/blockquote>\n<p>Polydatin and resveratrol look very similar chemically and have the same\u00a0<strong>antioxidant<\/strong>\u00a0and\u00a0<strong>anti-inflammatory effects<\/strong>, but the presence of a glucose molecule in the structure of polydatin makes it more\u00a0<strong>bioavailable<\/strong>, as it is more resistant to the action of enzymes and better absorbed by the intestine. In essence, supplementation with polydatin is more effective.<\/p>\n<div id=\"attachment_14846\" style=\"width: 1034px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" fetchpriority=\"high\" decoding=\"async\" aria-describedby=\"caption-attachment-14846\" class=\"wp-image-14846 size-large\" src=\"https:\/\/solongevity.com\/wp-content\/uploads\/2022\/03\/biomolecules-11-01048-g001-1-1024x356.png\" alt=\"\" width=\"1024\" height=\"356\" \/><p id=\"caption-attachment-14846\" class=\"wp-caption-text\">Resveratrol and Polydatin are very similar molecules, but the glucose ring in Polydatin&#8217;s structure makes it more bioavailable. Credit: Perrella et al., 2021<\/p><\/div>\n<h3>Polydatin and Covid, what\u2019s the relationship?<\/h3>\n<p>Because of its antioxidant and anti-inflammatory properties, polydatin is already used in\u00a0<strong>integrated medicine<\/strong>\u00a0in\u00a0<strong>oncology<\/strong>\u00a0where, together with other natural substances, it seems to benefit patients by mitigating toxicity and inflammation related to chemo and radiation therapy. Specifically in\u00a0<strong>cancer patients<\/strong>\u00a0on integrated polydatin therapy, despite being a category at risk of infection due to lowered immune defenses, experts from<a href=\"https:\/\/www.artoi.it\/en\/\">\u00a0Artoi<\/a>\u00a0(Integrated Oncology Therapies Research Association) noted a\u00a0<strong>lower incidence of Covid-19<\/strong>.<\/p>\n<p>Delving deeper into the issue, a team of researchers from the Federico II University of Naples, the CNR in Rome and Naples, and the Istituto Superiore di Sanit\u00e0 has highlighted how polydatin interacts with both coronavirus spike proteins and ACE-2 receptors in human cells,\u00a0<strong>hindering the entry of the virus<\/strong>\u00a0into cells (<a href=\"https:\/\/www.mdpi.com\/2218-273X\/11\/7\/1048\">the findings are reported in a paper published in the journal\u00a0<em>Biomolecules<\/em><\/a>). Hence the nickname \u201cbiological mask,\u201d although it should be pointed out that it is obviously not an antiviral and that further studies are needed.<\/p>\n<blockquote><p>Polydatin is more bioavailable than resveratrol, and supplementation is more effective<\/p><\/blockquote>\n<p>Taking polydatin through diet also appears to help<strong>\u00a0manage the consequences<\/strong>\u00a0<strong>of infection<\/strong>\u00a0in the medium and long term due to the molecule\u2019s anti-inflammatory and cytokine-modulating properties.<\/p>\n<p>Along with glutathione, resveratrol, and NAD+, polydatin is one of the so-called \u201c<strong>longevity molecules<\/strong>\u201d that\u00a0<a href=\"https:\/\/solongevity.com\/en\/nutraceutica\/\">SoLongevity research<\/a>\u00a0focuses on. On this site you can find an in-depth study dedicated to each molecule.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A polyphenol with antioxidant and anti-inflammatory properties, polydatin is a natural bioavailable molecule that also appears to reduce the infectivity of the coronavirus<\/p>\n","protected":false},"author":1,"featured_media":218,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[158,1],"tags":[164,168],"class_list":["post-14843","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en","category-non-categorizzato","tag-covid-en","tag-nutraceutics"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Polydatin and Coronavirus, What the Studies Say - SoLongevity<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/solongevity.com\/en\/longevity-news\/polydatin-and-coronavirus-what-the-studies-say\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Polydatin and Coronavirus, What the Studies Say - 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