{"id":14857,"date":"2022-08-19T16:13:08","date_gmt":"2022-08-19T16:13:08","guid":{"rendered":"https:\/\/solongevitypro.com\/?p=14857"},"modified":"2023-08-19T17:54:25","modified_gmt":"2023-08-19T17:54:25","slug":"nad-what-are-we-talking-about","status":"publish","type":"post","link":"https:\/\/solongevity.com\/en\/longevity-news\/nad-what-are-we-talking-about\/","title":{"rendered":"NAD+: What Are We Talking About?"},"content":{"rendered":"
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Nicotinamide Adenine Dinucleotide<\/h3>\n<\/div>\n
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Keeping healthy and young is also a matter of molecules. Discovered 90 years ago, the molecule Nicotinamide Adenine Dinucleotide (NAD, or rather\u00a0NAD+<\/strong>), also known as\u00a0coenzyme 1<\/strong>, is present in all cells and plays a central role in\u00a0metabolism<\/strong>, that is, the biochemical processes that lead to energy production. NAD+ influences several different cell functions, playing an important part in\u00a0DNA repair<\/strong>,\u00a0immune cell function<\/strong>, and\u00a0aging<\/strong>.<\/p>\n

Age goes up, NAD goes down<\/span><\/h3>\n<\/article>\n<\/div>\n<\/div>\n
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Scientists have found that as we age, the concentration of\u00a0NAD+<\/strong>\u00a0in cells and tissues gradually\u00a0declines<\/strong>, a decline that appears to contribute to various\u00a0diseases<\/strong>\u00a0including cognitive decline, cancers, metabolic diseases, bone fragility and sarcopenia.<\/article>\n
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La struttura molecolare di NAD<\/p><\/div>\n<\/article>\n

Over the past two decades, researchers\u00a0have shown<\/a>, first in animal models and then in some clinical studies, that levels of this molecule\u00a0can be increased<\/strong>, for example, by appropriate supplementation. The idea is that\u00a0supplements<\/strong>\u00a0containing the precursors of the NAD+ molecule, i.e., molecules used by the body to produce NAD+ such as the different forms of vitamin B3 (niacin, nicotinamide or NAM and nicotinamide riboside or NR) or nicotinamide mononucleotide (NMN), can help to raise its levels and counteract the effects of various diseases, as well as\u00a0increase<\/strong>\u00a0the length of life and, in particular, a\u00a0healthy life<\/strong>.<\/p>\n

NAD+ influences a number of cell functions, from metabolism to DNA repair, immune\u00a0cell function and\u00a0ageing.<\/p><\/blockquote>\n<\/article>\n<\/div>\n<\/div>\n

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NAD+ and sirtuins<\/h3>\n<\/div>\n
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In these early studies, supplement intervention has been shown to be safe and associated with\u00a0benefits<\/strong>\u00a0against age-related diseases and in slowing aging. High levels of NAD+, in fact, appear to\u00a0activate<\/strong>\u00a0sirtuins<\/a>, a group of 7 proteins (produced by the corresponding set of genes called SIRTs) involved in regulating the aging of cells, which use NAD+ itself to carry out their functions. Sirtuins generally become activated under conditions of a metabolic threat and stress (e.g., in the presence of cold temperatures or shortages of nutrients such as amino acids and sugars), reducing cell reproduction activities and thus allowing the organism to focus on\u00a0survival<\/strong>.<\/p>\n

NAD precursors<\/span><\/h3>\n<\/article>\n<\/div>\n<\/div>\n
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NAD+ precursors<\/strong>\u00a0are found in numerous\u00a0foods<\/strong>\u00a0of both\u00a0plant<\/strong>\u00a0(e.g., spinach, peanuts, avocado, broccoli, cabbage, and watermelon) and\u00a0animal<\/strong>\u00a0(such as cow\u2019s milk, white meat, salmon, swordfish, and tuna) origin. They are the subject of various\u00a0studies<\/strong>\u00a0testing their potential as components of\u00a0dietary supplements<\/strong>\u00a0to restore NAD+ levels, since diet alone may not be enough, and have been shown to be\u00a0stable<\/strong>\u00a0and\u00a0safe<\/strong>.Supplementation with these \u201cNAD boosters<\/strong>\u201d in laboratory research has shown very\u00a0promising<\/strong>\u00a0results, for example in animal models with obesity, diabetes and cardiovascular disease there have been benefits in terms of\u00a0weight reduction<\/strong>, increased\u00a0glucose tolerance<\/strong>\u00a0and improved\u00a0survival<\/strong>\u00a0rates. There is also evidence that they help\u00a0counteract neurodegeneration<\/strong>, with increased\u00a0memory<\/strong>, learning ability,\u00a0motor function<\/strong>, mitochondrial function, and\u00a0reduced neuron loss<\/strong>. They also appear to be able to prevent age-dependent changes in\u00a0gene expression<\/strong>. Results on humans are also encouraging; data which are currently available point in the same direction.<\/p>\n

Insieme al glutatione, al resveratrolo e alla polidatina, NAD+ \u00e8 una delle cosiddette \u201cmolecole della longevit\u00e0<\/b>\u201d su cui si concentra la\u00a0ricerca SoLongevity<\/a>. Su questo sito potrete trovare un approfondimento dedicato a ciascuna molecola.<\/p>\n

Along with glutathione, resveratrol, and polydatin, NAD+ is one of the so-called \u201clongevity molecules<\/strong>\u201d that\u00a0SoLongevity research<\/a>\u00a0focuses on. On this site you can find an in-depth study dedicated to each molecule.<\/p>\n<\/article>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

NAD+ is a molecule involved in cellular metabolism and aging. As the age increases, its level actually decreases. But with appropriate supplementation, it can be restored.<\/p>\n","protected":false},"author":1,"featured_media":141,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[158],"tags":[160,168,172],"class_list":["post-14857","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en","tag-active-ageing","tag-nutraceutics","tag-sirtuins"],"acf":[],"yoast_head":"\nWhat is NAD+ for, and in which Anti Age nutraceuticals is it found? - SoLongevity<\/title>\n<meta name=\"description\" content=\"What is the function of NAD+ in cellular metabolism and aging? 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