{"id":16654,"date":"2022-10-22T10:05:19","date_gmt":"2022-10-22T10:05:19","guid":{"rendered":"https:\/\/solongevitypro.com\/longevity-news\/urolithin-a-promotes-maintenance-of-mitochondria-and-muscles\/"},"modified":"2022-12-14T08:44:14","modified_gmt":"2022-12-14T08:44:14","slug":"urolithin-a-promotes-maintenance-of-mitochondria-and-muscles","status":"publish","type":"post","link":"https:\/\/solongevity.com\/en\/longevity-news\/urolithin-a-promotes-maintenance-of-mitochondria-and-muscles\/","title":{"rendered":"Urolithin A Promotes \u2018Maintenance\u2019 of Mitochondria and Muscles"},"content":{"rendered":"<h3>What is the role of mitochondria?<\/h3>\n<p>Cells are extremely complex biological machines. They can do a little bit of everything by exploiting the information encoded in their <strong>DNA<\/strong>, but to accomplish this they obviously need fuel. Providing it are the <strong>mitochondria<\/strong>, the so-called energy powerhouses of cells, where fatty sugars and proteins taken in with food are converted into <strong>ATP<\/strong>, the main ingredient in all the processes involved in <strong>cellular metabolism<\/strong>. As we age, however, mitochondria become less and less efficient at producing energy, contributing to the decline in our physical capabilities. Fortunately, some substances can help counteract the effects of time: this appears to be the case with<strong>urolithin A,<\/strong>supplementation of which-demonstrates a study in <a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2788244\" target=\"_blank\" rel=\"noopener\"><em>Jama Network Open<\/em><\/a> Jama Network Open-could help keep cells healthy and give our muscles strength by acting on a \u201cmaintenance\u201d process of mitochondria known as <strong>mitophagy.<\/strong>.<\/p>\n<h3>What is mitophagy?<\/h3>\n<p>\u201cMitochondria are like batteries that power the cells in our bodies,\u201d explains David Marcinek, a radiologist at the University of Washington who led the research. \u201cOver time they can fail, and with mitophagy, cells recognize the onset of these problems and eliminate damaged mitochondria, reducing them to their essential components that can then be reused. As we age, however, mitophagy becomes less efficient and the body accumulates an increasing number of malfunctioning mitochondria. And this is one reason why muscles become progressively less \u2018resistant\u2019 as we age.\u201d<\/p>\n<p><img fetchpriority=\"high\" fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-839 size-full\" src=\"https:\/\/solongevity.com\/wp-content\/uploads\/2022\/11\/shutterstock_1783218587.jpg\" alt=\"\" width=\"1000\" height=\"667\" srcset=\"https:\/\/solongevity.com\/wp-content\/uploads\/2022\/11\/shutterstock_1783218587.jpg 1000w, https:\/\/solongevity.com\/wp-content\/uploads\/2022\/11\/shutterstock_1783218587-300x200.jpg 300w, https:\/\/solongevity.com\/wp-content\/uploads\/2022\/11\/shutterstock_1783218587-768x512.jpg 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/p>\n<blockquote><p>Urolithin A supplementation could help maintain healthy cells and give strength to our muscles by acting on a \u201cmaintenance\u201d process of mitochondria<\/p><\/blockquote>\n<h3>What is urolithin A?<\/h3>\n<p>Urolithin A is produced in our bodies by <strong>gut bacteria<\/strong> and is promoted by a diet rich in <strong>polyphenols<\/strong>, such as those found in, for example, <strong>pomegranates<\/strong>, <strong>berries<\/strong>, and <strong>nuts<\/strong>. Because diet, age, genetics, and disease affect the composition of the <strong>gut microbiome<\/strong>, people produce urolithin A at different rates.<\/p>\n<h3>What does the new study on urolithin A show?<\/h3>\n<p>Already in the past, some research in animal models and humans had shown that urolithin A could increase the ability of cells to perform mitophagy properly. And for this reason, Marcinek and his team decided to test whether urolithin supplementation could have an effect on the muscle capacity of people who, due to age, have an increasing number of malfunctioning mitochondria in their bodies. In all, 66 people over 60 participated in the study. Half of them took <strong>one gram of urolithin A every day for a month<\/strong>, and at the end of the experiment the researchers evaluated the physical abilities of the two groups and the effectiveness of their mitochondria in producing energy.<\/p>\n<blockquote><p>As we age, mitophagy becomes less efficient and the body accumulates an increasing number of malfunctioning mitochondria.<\/p><\/blockquote>\n<h3>What could be the benefit of urolithin A supplementation?<\/h3>\n<p>The results showed an improvement in the muscle capacity of the group taking urolithin A, particularly in <strong>fatigue endurance<\/strong> during consecutive contractions of the <strong>hand and leg muscles<\/strong>. In contrast, no differences emerged between the two groups in the ability to produce ATP, but lower levels of substances such as <strong>acylcarnitine<\/strong> and <strong>ceramides<\/strong>, which are linked to the onset of metabolic disorders involving the mitochondria, were detected in subjects taking urolithin. A clue, the researchers write, to the beneficial effects of urolithin A.<\/p>\n<p>\u201cThese changes may suggest that the treatment affects people\u2019s metabolic conditions,\u201d Marcinek explained, \u201cAlthough it did not improve maximum ATP production, it still improved the participants\u2019 overall <strong>metabolism<\/strong>.\u201d Urolithin A, taken under medical supervision, could therefore be useful for those who are unable to get some exercise because of <strong>muscle weakening<\/strong> related to aging or the onset of <strong>chronic disease<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>An American study measured the effects of urolithin A supplementation on muscle endurance and mitochondrial health. The results suggest that the substance aids a process called mitophagy, by which cells replace damaged mitochondria<\/p>\n","protected":false},"author":1,"featured_media":574,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[158],"tags":[159,169],"class_list":["post-16654","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en","tag-longevity-science-en","tag-nutrition"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Urolithin A Promotes \u2018Maintenance\u2019 of Mitochondria and Muscles - SoLongevity<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/solongevity.com\/en\/longevity-news\/urolithin-a-promotes-maintenance-of-mitochondria-and-muscles\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Urolithin A Promotes \u2018Maintenance\u2019 of Mitochondria and Muscles - SoLongevity\" \/>\n<meta property=\"og:description\" content=\"An American study measured the effects of urolithin A supplementation on muscle endurance and mitochondrial health. 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