{"id":23796,"date":"2023-06-23T15:35:34","date_gmt":"2023-06-23T15:35:34","guid":{"rendered":"https:\/\/solongevity.com\/longevity-news\/lipoprotein-a-new-guidelines-for-cardiovascular-risk-management\/"},"modified":"2023-06-23T15:35:34","modified_gmt":"2023-06-23T15:35:34","slug":"lipoprotein-a-new-guidelines-for-cardiovascular-risk-management","status":"publish","type":"post","link":"https:\/\/solongevity.com\/en\/longevity-news\/lipoprotein-a-new-guidelines-for-cardiovascular-risk-management\/","title":{"rendered":"Lipoprotein A, new guidelines for cardiovascular risk management"},"content":{"rendered":"<h3>What are the new scientific indications on Lipoprotein A and cardiovascular risk?<\/h3>\n<p>It is a silent enemy of the <strong>heart<\/strong> and <strong>blood vessels<\/strong>. Less known, but probably no less dangerous, than other <strong>risk factors<\/strong> more often put in the spotlight, such as <strong>high levels of LDL cholesterol<\/strong>, <strong>triglycerides<\/strong>, <strong>blood sugar <\/strong>or <strong>blood pressure<\/strong>. We are talking about<strong> lipoprotein A <\/strong> (Lp(a)), which is responsible for cholesterol transport in the blood: at <strong>high concentrations<\/strong> it poses a danger in terms of<strong> atherosclerotic cardiovascular disease<\/strong> and <strong>aortic valve stenosis<\/strong>. A consensus <strong><a href=\"https:\/\/academic.oup.com\/eurheartj\/article\/43\/39\/3925\/6670882?login=false\" target=\"_blank\" rel=\"noopener\">document<\/a><\/strong> from the European Atherosclerosis Society reminds us of this today, which a decade after a statement on Lp(a) returns to the issue, with some fine-tuning. The goal is to provide <strong>clinical guidance<\/strong> for testing and treating elevated levels of Lp(a)-a condition that affects more than <strong>20 percent of the general population<\/strong>, and even more so individuals with coronary artery disease-and to include the results of this analysis in estimating global <strong>cardiovascular risk<\/strong>.<\/p>\n<h3>Increased cardiovascular risk<\/h3>\n<p>The starting point, says the study published in October in the <em>European Heart Journal,<\/em> whose authors include Alberico Catapano of the Department of Pharmacology at the University of Milan, is the strong evidence for a <strong>causal association between Lp(a) concentrations and cardiovascular outcomes<\/strong>. What is new is the concept of the risk threshold, which is highlighted in this new document. In practice, therefore,<strong> cardiovascular risk increases as Lp(a) concentration increases<\/strong> in both men and women.<\/p>\n<h3>Measuring lipoprotein A<\/h3>\n<p>A second important message emphasized by the new study is that <strong>Lp(a) interacts with other factors in increasing overall cardiovascular risk<\/strong>. In other words, this is higher in people with high Lp(a) levels and a low cardiovascular health score, compared with those who still have high Lp(a) levels but generally good cardiovascular health. Therefore, the key message of the European Atherosclerosis Society paper, is that <strong>it is important that lipoprotein be measured at least once in adults<\/strong> through specific tests.<\/p>\n<h3>A guide for physicians<\/h3>\n<p><strong>There are not yet any specific therapies<\/strong> for this condition, although some molecules are in phase II\/III clinical trials. Therefore, the consensus document points out that it is important for physicians to have clear guidance on how to <strong>manage the excess risk<\/strong> associated with high Lp(a) concentration. Previous guidelines recommended <strong>acting on risk factors<\/strong>, but did not provide specific information on how to tailor interventions for the individual patient. Instead, the new statement is a guide for optimal management of the risk associated with lipoprotein A by also considering the other major risk factors, for example by acting on<strong> LDL cholesterol reduction<\/strong> or with interventions on <strong>blood pressure<\/strong>. Always remembering that <strong>the earlier the intervention is started, the greater the impact on cardiovascular risk<\/strong> over a lifetime.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A consensus document from the European Atherosclerosis Society gives physicians new guidance for testing and treating high blood Lp(a) concentrations<\/p>\n","protected":false},"author":14,"featured_media":23526,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[158],"tags":[159,170],"class_list":["post-23796","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en","tag-longevity-science-en","tag-prevention"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Lipoprotein A, new guidelines for cardiovascular risk management - 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