{"id":4030,"date":"2021-09-22T08:49:00","date_gmt":"2021-09-22T08:49:00","guid":{"rendered":"https:\/\/solongevity.com\/?p=4030"},"modified":"2022-12-14T08:44:19","modified_gmt":"2022-12-14T08:44:19","slug":"covid-19-why-are-obese-people-more-at-risk","status":"publish","type":"post","link":"https:\/\/solongevity.com\/en\/longevity-news\/covid-19-why-are-obese-people-more-at-risk\/","title":{"rendered":"Covid-19, why are obese people more at risk?"},"content":{"rendered":"
\n While the main predisposing factor for the development of severe forms of <\/span>Covid-19<\/b> is <\/span>old age<\/b>, obesity comes next. How comes? What do these two conditions have in common? Both appear to <\/span>reduce the body’s ability to fight infection<\/b> by weakening the immune system and promoting <\/span>inflammation<\/b>. The point is made in an <\/span>article published in Nature<\/span><\/a> (in the <\/span>Features – Collection section, ‘Nutrition, immunity and a global pandemic’<\/span><\/a>, in collaboration with another journal in the same group, <\/span>European Journal of Clinical Nutrition and Nutrition & Diabetes<\/span><\/a>).<\/span><\/div>\n\r\n\r\n
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Age, the biggest risk factor for any disease<\/b><\/em><\/p>\n<\/div>\n\r\n\r\n

\n Ageing and its consequences<\/b> are a much-studied phenomenon. It is easy to see why: old age is linked to a <\/span>variety of diseases<\/b>, many of which, if you dig deeper, turn out to have an <\/span>inflammatory basis<\/b>. Although there is still much to be uncovered, scientists have produced enough evidence to be reasonably sure that <\/span>as time passes, the immune system changes<\/b>, becoming less active in some ways and hyper-reactive in others. As a result, it is no longer as efficient at fighting infection.<\/span><\/div>\n\r\n\r\n
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Obesity, an accelerator?<\/h3>\n Experts believe that obesity may <\/span>accelerate<\/b> the ageing of the immune system.<\/span>\r\n\r\nWhile <\/span>adipose tissue<\/b> normally plays an anti-inflammatory and protective role, when it becomes too much it can become <\/span>dysfunctional<\/b>, secreting hormones and other chemical signals that instead promote what is called a <\/span>chronic low-grade inflammatory state<\/b>. A condition similar, in fact, to that which develops with the passing of the years and which increases the risk of developing disorders such as <\/span>cardiovascular diseases, autoimmune diseases, tumours<\/b>, etc. Thus, it is no coincidence that a <\/span>high body mass index <\/b>is associated with.<\/span><\/div>\n\r\n\r\n
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Obesity seems to accelerate the ageing of the immune system<\/i><\/b><\/p>\n<\/div>\n\r\n\r\n

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Three possible mechanisms<\/h3>\n How chronic low-grade inflammation is promoted by excess adipose tissue is still under investigation, but there are several hypotheses. Some experts think that the overload of nutrients within adipocytes (fat cells) causes <\/span>intercellular stress<\/b> that initiates an <\/span>inflammatory cascade<\/b>. Others believe that adipose tissue becomes <\/span>hypoxic<\/b> and, in the absence of oxygen, activates inflammatory mechanisms. A third possibility is that immune system cells (macrophages) infiltrate the overabundant adipose tissue and try hard to get rid of the dying parts. This generates <\/span>toxicity<\/b>, triggering a cascade of reactions that contribute to the body’s chronic inflammatory state.<\/span>\r\n\r\nObesity<\/b>, however, is considered a risk factor for Covid-19 not only because of its contribution to chronic inflammation. In fact, being <\/span>overweight<\/b> is very often associated with <\/span>type 2 diabetes<\/b> and <\/span>respiratory difficulties<\/b>, which in turn expose people to an increased risk of Sars-Cov-2 infection complications.<\/span><\/div>\n\r\n\r\n
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The role of nutrition<\/h3>\n Our <\/span>diet<\/b> also contributes to low-grade chronic inflammation. According to an article published in 2019 in the journal Nutrients, the diet of <\/span>Western countries<\/b> (high-income) has been enriched in sugars and fats and depleted in complex carbohydrates, fibre and micronutrients: an unhealthy combination that promotes so-called <\/span>chronic metabolic inflammation<\/b> and alters the <\/span>gut microbiota<\/b>, increasing the production of <\/span>toxins<\/b>. Obesity also predisposes to altered <\/span>intestinal permeability<\/b>. This means that more toxins pass from the gut into the bloodstream, inducing a further<\/span> inflammatory response<\/b>.<\/span>\r\n\r\n\"\" The Mediterranean diet, rich in foods containing antioxidants, polyphenols and omega-3 fats, can help reduce chronic inflammation linked to obesity.<\/div>\n\r\n\r\n
\n

Excess adipose tissue could trigger an inflammatory cascade<\/b><\/p>\n<\/div>\n\r\n\r\n

\n Eating well is therefore essential for everyone and can help reduce the damage caused by age-related problems and being overweight. The <\/span>Mediterranean diet <\/b>is still considered the best, because it provides <\/span>antioxidants, polyphenols and omega-3<\/b> that work to reduce inflammation. These are molecules that have been shown to be effective and have even been studied as ingredients in <\/span>food supplements<\/b> to support the immune system and reverse chronic inflammation processes.<\/span><\/div>\n\r\n\r\n
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Losing weight keeps us safe<\/h3>\n Adjusting our <\/span>diet and exercising<\/b> (even moderate exercise, such as a 20-minute walk) can not only help to decrease chronic low-grade inflammatory status, but also help to maintain a healthy weight or <\/span>lose excess weight<\/b>. According to Andrew Greenberg of the Jean Mayer USDA Human Nutrition Research Center on Aging, “even <\/span>losing 5 to 10 per cent of weight really helps<\/b> a person improve their metabolic profile”.<\/span><\/div>\n\r\n\r\n <\/div>\n
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Bibliography .<\/h3>\n Nature.com: https:\/\/www.nature.com\/articles\/d42859-021-00051-w?utm_source=facebook&utm_medium=social&utm_campaign=-nutrition_immunity&utm_content=post_2&fbclid=IwAR1iRQyomzKHi_8SAZFP6P1OxFJiwunWVli6DEYysaDfniZOf2-CubGNbUM<\/a>\u00a0<\/span> <\/div>\n<\/div>\n\r\n\r\n
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\n News <\/div>\n

Covid-19, why are obese people more at risk?<\/h2>\n

Obesity is one of the main risk factors for the development of severe forms of Covid-19: according to the experts, chronic inflammation and an altered immune system are involved. Just as it does when you get older.<\/p>\n <\/div>\n

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Leggi l'articolo<\/p>\n <\/div>\n <\/a>\n <\/div>\n

\n \n \"\"\n
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\n News <\/div>\n

Covid-19, why are obese people more at risk?<\/h2>\n

Obesity is one of the main risk factors for the development of severe forms of Covid-19: according to the experts, chronic inflammation and an altered immune system are involved. Just as it does when you get older.<\/p>\n <\/div>\n

\n

Leggi l'articolo<\/p>\n <\/div>\n <\/a>\n <\/div>\n

\n \n \"\"\n
\n
\n News <\/div>\n

Covid-19, why are obese people more at risk?<\/h2>\n

Obesity is one of the main risk factors for the development of severe forms of Covid-19: according to the experts, chronic inflammation and an altered immune system are involved. Just as it does when you get older.<\/p>\n <\/div>\n

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Leggi l'articolo<\/p>\n <\/div>\n <\/a>\n <\/div>\n <\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Obesity is one of the main risk factors for the development of severe forms of Covid-19: according to the experts, chronic inflammation and an altered immune system are involved. Just as it does when you get older.<\/p>\n","protected":false},"author":1,"featured_media":74,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[158,60],"tags":[164,169],"class_list":["post-4030","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en","category-old-posts","tag-covid-en","tag-nutrition"],"acf":[],"yoast_head":"\nCovid-19 why are obese people more at risk<\/title>\n<meta name=\"description\" content=\"Obesity is one of the main risk factors for the development of severe forms of Covid-19: according to the experts, chronic inflammation and an altered immune system are involved. 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