{"id":40753,"date":"2025-06-24T10:34:38","date_gmt":"2025-06-24T10:34:38","guid":{"rendered":"https:\/\/solongevity.com\/longevity-news\/biohacking-which-technologies-accelerate-rejuvenation\/"},"modified":"2026-10-16T17:14:07","modified_gmt":"2026-10-16T17:14:07","slug":"biohacking-rejuvenation-technologies","status":"publish","type":"post","link":"https:\/\/solongevity.com\/en\/longevity-news\/biohacking-rejuvenation-technologies\/","title":{"rendered":"Biohacking: Which Technologies Accelerate Rejuvenation"},"content":{"rendered":"

What is biohacking?<\/h2>\n

Our body possesses \u201cby nature\u201d biological mechanisms that help us respond to environmental stress. And these very systems can now be exploited to counter aging. This is the concept behind so-called biohacking<\/strong><\/em>, that is, the set of interventions which, by artificially mimicking environmental stressors<\/strong> such as calorie restriction<\/strong> or physical exercise<\/strong>, are able to stimulate certain metabolic pathways to make them more efficient, in order to improve our state of health over time. <\/p>\n

The scientific evidence on the Accelerators of physiological rejuvenation<\/h2>\n

There is a broad body of studies analyzing methods and technologies to stimulate the cellular pathways that respond to environmental stress. Underlying them is the principle that our body \u2014 like that of all living beings \u2014 responds to specific physical and chemical laws: the field of research is therefore that of biophysics and biochemistry applied to human physiology. This topic is also at the center of SoLongevity’s research, where these therapeutic interventions are called \u201cAccelerators of physiological rejuvenation<\/strong>\u201d, a name that in our opinion is more correct than the generic biohacking, because they aim to enhance the biological anti-aging mechanisms<\/strong> in a targeted way. <\/p>\n

The principle on which they are based is that of hormesis<\/strong>: an adaptive function whereby a modest stimulation is followed by a much greater reaction by the body.<\/p><\/blockquote>\n

What are some examples of biohacking?<\/h2>\n

In the scientific literature there are a great many therapeutic interventions, but not all of them have a solid rationale explaining how they work or solid evidence of efficacy. Among those that have been the subject of randomized controlled clinical trials, including in humans, and for which reliable data exist, we find: <\/p>\n

    \n
  1. Cyclic hypoxia-hyperoxia therapy (IHHT, Intermittent hypoxic hyperoxic training)<\/li>\n
  2. Breath therapy<\/li>\n
  3. Infusion or intravenous (IV) therapies<\/li>\n
  4. Ozone therapy<\/li>\n
  5. Red and infrared light treatment (Photobiomodulation)<\/li>\n
  6. Molecular hydrogen therapy<\/li>\n<\/ol>\n

    These are the Accelerators of physiological rejuvenation used in our SoLongevity Clinic<\/strong> by specialized medical staff<\/strong>: for all of them, there is evidence of efficacy both at the physiological level and at the level of the biological mechanisms (hallmarks<\/strong>) of aging. Let us look at them in more detail. <\/p>\n

    1 – What is hypoxia-hyperoxia therapy?<\/h2>\n

    Intermittent hypoxic-hyperoxic therapy<\/strong> is a therapeutic protocol that works on cycles of exposure to conditions of hypoxia (low oxygen levels) and hyperoxia (high oxygen levels), using a special medical device that recreates conditions similar to high-altitude training<\/strong>, above 3,000 meters.<\/p>\n

    In general, each cycle involves 4 intervals of 10 minutes each. The training, however, must be personalized<\/strong> according to the person’s characteristics, for their safety: blood oxygen saturation levels must always remain above the critical threshold. <\/p>\n

    What are the benefits of cyclic hypoxia-hyperoxia therapy?<\/h3>\n

    By the principle of hormesis, controlled hypoxia puts stress on cells which, in the absence of oxygen, are stimulated to activate the mechanisms that allow them to make the best use of the resources available. The Hypoxia Inducible factor<\/strong> (HIF) complex is also stimulated, which modulates multiple cellular pathways, including those linked to senescence<\/strong>, oxidative stress<\/strong>, inflammation<\/strong>, glycolysis<\/strong> and apoptosis<\/strong> (programmed cell death). <\/p>\n

    Who it is recommended for<\/h3>\n

    This treatment is recommended for cardiovascular prevention<\/strong>, to enhance cardiopulmonary capacity<\/strong> and neurocognitive<\/strong> capacity, and to improve microcirculation<\/strong>.<\/p>\n

    2 – What is breath therapy?<\/h2>\n

    Breath training<\/strong> is a SoLongevity therapeutic program that aims to teach correct breathing from a technical point of view and the correct use of the muscles supporting biomechanical function.<\/p>\n

    The aim is to recover optimal respiratory function or to enhance it if required, for example to improve sports performance. In more detail, to: <\/p>\n