{"id":40791,"date":"2024-07-08T12:43:19","date_gmt":"2024-07-08T12:43:19","guid":{"rendered":"https:\/\/solongevity.com\/longevity-news\/genetics-is-not-necessarily-our-destiny\/"},"modified":"2026-10-19T08:17:18","modified_gmt":"2026-10-19T08:17:18","slug":"genetics-not-our-destiny","status":"publish","type":"post","link":"https:\/\/solongevity.com\/en\/longevity-news\/genetics-not-our-destiny\/","title":{"rendered":"Genetics Is Not Necessarily Our Destiny"},"content":{"rendered":"<p>How important the <strong>role of genetics<\/strong> is in determining the length and quality of life is still an area of debate in the scientific community. An important contribution to this debate comes from a <a href=\"https:\/\/ebm.bmj.com\/content\/early\/2024\/04\/16\/bmjebm-2023-112583\" target=\"_blank\" rel=\"noopener\">study<\/a> published in <em>BMJ Evidence-Based Medicine<\/em> that examined the association between genetic factors and lifestyle and human lifespan, using data collected from the largest registry of its kind in the world, the UK&#8217;s <strong>UK Biobank<\/strong>. The data included more than <strong>350,000 people<\/strong>, followed for a period of about 12 years, and the modifiable risk factors included were: alcohol, smoking, physical activity, sleep duration and diet.  <\/p>\n<h3>What the Polygenic Risk Score is<\/h3>\n<p>The patients were divided according to their genetic risk measured through the <strong>PRS<\/strong> (<strong>Polygenic Risk Score<\/strong>), splitting them into categories. This method makes it possible to analyze<strong> hundreds of genes<\/strong> simultaneously and weigh their cumulative impact, using very sophisticated algorithms. <\/p>\n<p>The results revealed that a high genetic risk, measured through the PRS, is correlated with a <strong>21%<\/strong> increase in the risk of early death (before age 75) compared with a low genetic risk, regardless of lifestyle. Conversely, an unfavorable lifestyle is associated with an increase in the risk of death of about <strong>78%<\/strong> compared with a favorable lifestyle, within and across genetic risk categories. <\/p>\n<div class=\"container-product-box\"><div class=\"product-box\"> <div class=\"badge\">SOLONGEVITY SHOP<\/div>    <div class=\"product-image\">        <img decoding=\"async\" src=\"https:\/\/shop.solongevity.com\/cdn\/shop\/files\/solongevity-body_mind-program.jpg?v=1702630418&#038;width=700\" alt=\"Body&amp;Mind Program\">    <\/div>    <div class=\"product-details\">        <div class=\"product-title\">Body&amp;Mind Program        <\/div>        <div class=\"product-description\">Lo stile di vita agisce a livello epigenetico, modificando l'espressione dei geni correlati a fattori di rischio. Un programma di integrazione nutrizionale pu\u00f2 aiutare a mantenere in salute il sistema cardiovascolare e il sistema nervoso.        <\/div>        <div class=\"price-and-button\">            <div class=\"product-button\">                <a class=\"button\" href=\"https:\/\/shop.solongevity.com\/products\/body-mind?utm_source=corporate&#038;utm_medium=genetics-not-our-destiny&#038;utm_campaign=banner\">Scopri di pi\u00f9 <\/a>            <\/div>        <\/div>    <\/div><\/div><\/div>\n<h3>More than 5 extra years of healthy life<\/h3>\n<p>However, adherence to healthy lifestyles emerged as a factor capable of significantly attenuating the genetic risk of a shorter lifespan or premature death, with an extremely important finding: individuals with a high genetic risk could extend their lifespan by about <strong>5.22 years<\/strong> at age 40 by adopting a favorable lifestyle.<\/p>\n<p>This leads us to reflect on at least 4 different themes:<\/p>\n<p>1 &#8211; That adherence to a <strong>healthy lifestyle<\/strong> could significantly offset an unfavorable genetic risk of a shorter lifespan or premature death, leading to a substantial increase in <strong>longevity<\/strong>, understood not only as length of life (<em><strong>lifespan<\/strong><\/em>) but also as years of life in good health (<em><strong>healthspan<\/strong><\/em>).<\/p>\n<p>2 &#8211; The importance of a <strong>predictive genetic analysis<\/strong> that also includes the PRS, which could identify the people most at risk early on, ensuring a targeted and personalized intervention, all the more so if risk factors are present.<\/p>\n<p>3 &#8211; The crucial importance of public health policies and of the concept of <strong>prevention and health promotion<\/strong>, aimed at improving people&#8217;s lifestyles, which must start first and foremost with us health professionals, but also with people themselves.<\/p>\n<p>4 &#8211; That <strong>genetics<\/strong> is not our destiny.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A large study conducted in the United Kingdom shows that individuals with a high genetic risk can extend their life expectancy by adopting a healthy lifestyle<\/p>\n","protected":false},"author":14,"featured_media":27904,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[158],"tags":[357,165,169,170],"class_list":["post-40791","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en","tag-epigenetics","tag-exercise","tag-nutrition","tag-prevention"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Genetics Is Not Necessarily Our Destiny - SoLongevity<\/title>\n<meta name=\"description\" content=\"When it comes to longevity, genetics certainly plays an important role. 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