{"id":40878,"date":"2022-05-26T11:20:06","date_gmt":"2022-05-26T11:20:06","guid":{"rendered":"https:\/\/solongevity.com\/longevity-news\/fine-particulate-matter-fuels-inflammation-by-lowering-a-sirtuin\/"},"modified":"2026-10-19T15:09:41","modified_gmt":"2026-10-19T15:09:41","slug":"fine-particulate-matter-inflammation-sirtuin","status":"publish","type":"post","link":"https:\/\/solongevity.com\/en\/longevity-news\/fine-particulate-matter-inflammation-sirtuin\/","title":{"rendered":"Fine Particulate Matter Fuels Inflammation by Lowering a Sirtuin"},"content":{"rendered":"<div id=\"title_text-block_623c6419c27ba\">\n          <p lang=\"it-IT\" align=\"LEFT\"><em><span style=\"font-weight: 400\">PM2.5 particulate matter lowers the levels of a protein, sirtuin 2, which regulates important physiological processes underlying<\/span><span style=\"font-weight: 400\"> the<\/span><\/em><span style=\"font-weight: 400\"><em>inflammation of the airways. This is revealed by a study that also identifies a potential therapeutic avenue <\/em><\/span><\/p>\n<p lang=\"it-IT\" align=\"LEFT\">\n<p><b><i>What this article is about<\/i><\/b><\/p>\n<ul>\n<li><span style=\"font-weight: 400\">A mechanism has been discovered through which PM2.5 fine particulate matter promotes airway inflammation<\/span><\/li>\n<li><span style=\"font-weight: 400\">It has been observed that PM2.5 reduces sirtuin 2 levels and that it is precisely this mechanism that triggers the inflammatory process<\/span><\/li>\n<li><span style=\"font-weight: 400\">In mice, a compound called triptolide has been shown to be able to inhibit inflammation<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><b><i>Related articles<\/i><\/b><\/p>\n<ul>\n<li><a href=\"https:\/\/solongevity.com\/en\/longevity-news\/the-chronic-inflammation-that-gets-us-old\/\">Inflammaging, the chronic inflammation that makes us age<\/a><\/li>\n<li><a href=\"https:\/\/solongevity.com\/en\/longevity-news\/sirtuins-the-7-genes-that-make-us-live-longer-2\/\">Sirtuins, the 7 genes that make us live longer and better<\/a><\/li>\n<li><a href=\"https:\/\/solongevity.com\/en\/longevity-news\/the-risk-of-disease-dice-your-clock-inflammatory\/\">The risk of disease? Your \u201cinflammatory clock\u201d tells you <\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"title_text-block_623c5db9c27b1\">\n          <p><span style=\"font-weight: 400\">Italy ranks first in Europe for the number of deaths due to fine particulate matter, according to data from a recent study in <\/span><a href=\"https:\/\/www.lancetcountdown.org\/2019-report\/\"><i><span style=\"font-weight: 400\">The Lancet<\/span><\/i><\/a><span style=\"font-weight: 400\">, and eleventh for deaths from <\/span><b>PM2.5 fine particulate matter<\/b><span style=\"font-weight: 400\">. PM2.5 damages the <\/span><b>lungs<\/b><span style=\"font-weight: 400\"> and other organs and tissues, increasing the risk of <\/span><b>respiratory infections<\/b><span style=\"font-weight: 400\">, various types of cancer, heart disease and more. Now, a study conducted by the Air Force Medical University, a Chinese military institution dedicated to academic training, has identified a possible mechanism through which PM2.5 particulate matter would trigger <\/span><b>inflammation<\/b><span style=\"font-weight: 400\"> in the <\/span><b>airways<\/b><span style=\"font-weight: 400\">. Understanding the origins of this process is important for identifying new preventive strategies and possible therapeutic targets. The key would lie in  <\/span><b>sirtuins<\/b><span style=\"font-weight: 400\">, a group of 7 proteins that are very important for our body, and in particular in one of them, <\/span><b>sirtuin 2 <\/b><span style=\"font-weight: 400\">(<\/span><b>SIRT2<\/b><span style=\"font-weight: 400\">). The results, so far obtained in an animal model, are <\/span><a href=\"https:\/\/journal.hep.com.cn\/fmd\/EN\/10.1007\/s11684-021-0839-4\"><span style=\"font-weight: 400\">published in the journal <\/span><i><span style=\"font-weight: 400\">Frontiers in Medicine<\/span><\/i><\/a><span style=\"font-weight: 400\">.<\/span> <\/p>\n<\/div>\n<div id=\"title_text-block_623c5e4dc27b2\">\n        <h3 class=\"article-title\">PM2.5 fine particulate matter<\/h3>\n          <p><span style=\"font-weight: 400\">PM2.5 particulate matter is made up of particles with a size equal to or smaller than 2.5 micrometers (thousandths of a millimeter). These  <\/span><b>very fine particles <\/b><span style=\"font-weight: 400\">can enter the <\/span><b>bronchi<\/b><span style=\"font-weight: 400\">. Moreover, unlike coarser particulate matter, such as <\/span><b>PM10<\/b><span style=\"font-weight: 400\">, they can also reach the pulmonary alveoli and from there pass into the blood.<\/span><\/p>\n<p><span style=\"font-weight: 400\">The scientists showed that PM2.5 is able to cause airway inflammation and bronchial hyperreactivity in mice. The research identified a possible gear behind the \u201cmachine\u201d of inflammation. The mechanism is complex and consists of several steps.  <\/span><\/p>\n<\/div>\n<div id=\"custom_quote-block_623c5e70c27b3\" class=\"quote\">\n  <p class=\"quote\"><em><strong>PM2.5 fine particulate matter reaches the bronchi and pulmonary alveoli, and from there manages to pass into the blood<\/strong><\/em>\n<\/p>\n<\/div>\n<div id=\"title_text-block_623c5e87c27b4\">\n        <h3 class=\"article-title\">A complex gear<\/h3>\n          <p><span style=\"font-weight: 400\">Sirtuins also play a role in these steps: proteins naturally produced by our body that regulate important metabolic processes and that exert an <\/span><b>\u201canti-aging\u201d action<\/b><span style=\"font-weight: 400\"> on cells, helping to prevent numerous diseases. We already knew that sirtuin 2 acts as a mediator within a physiological process at the root of inflammation. More specifically, SIRT2 modulates certain chemical reactions involving another protein, abbreviated p65, which in turn underlies the activation of the protein complex NF-\u03baB. The latter plays an essential part in inflammation and in   <\/span><b>innate immunity<\/b><span style=\"font-weight: 400\">, the first line of defense we have from birth, and also plays a role in the development and progression of cancer. The NF-\u03baB protein is activated in all the reactions of cells stimulated by external stimuli, including attacks by viruses, bacteria and other pathogens.  <\/span><\/p>\n<p><img fetchpriority=\"high\" fetchpriority=\"high\" decoding=\"async\" fetchpriority=\"high\" class=\"alignnone size-full wp-image-9190\" src=\"https:\/\/solongevity.com\/wp-content\/uploads\/2022\/11\/shutterstock_1617828388.jpg\" alt=\"\" width=\"1000\" height=\"667\"><\/p>\n<\/div>\n<div id=\"custom_quote-block_623c5e9dc27b5\" class=\"quote\">\n  <p class=\"quote\"><strong><em>The scientists showed that PM2.5 is able to cause airway inflammation and bronchial hyperreactivity in mice<\/em><\/strong>\n<\/p>\n<\/div>\n<div id=\"title_text-block_623d9ea092112\">\n        <h3 class=\"article-title\">How PM2.5 acts<\/h3>\n          <p><span style=\"font-weight: 400\">In the study, the scientists found that exposure to PM2.5 fine particulate matter reduces sirtuin 2 (SIRT2) levels in bronchial tissues. This drop activated specific chemical reactions of the p65 protein that triggered the physiological pathway at the origin of airway inflammation. In the study, the inflammation subsequently promoted excessive bronchial reactivity and a thickening of certain parts of the tissue in the mice. In addition, mucus secretion was greater and the researchers observed a narrowing of the trachea. In animals in which SIRT2 had been silenced in the laboratory, the inflammation and deterioration were more marked.    <\/span><\/p>\n<\/div>\n<div id=\"custom_quote-block_623c5f89c27b8\" class=\"quote\">\n  <p class=\"quote\"><em><strong>PM2.5 reduces sirtuin 2 levels and in this way triggers the process that leads to airway inflammation<\/strong><\/em>\n<\/p>\n<\/div>\n<div id=\"title_text-block_623d9f1392113\">\n          <p><span style=\"font-weight: 400\">There is some good news: the researchers found that <\/span><b>triptolide<\/b><span style=\"font-weight: 400\">, a compound known as an <\/span><b>inhibitor of the p65 protein<\/b><span style=\"font-weight: 400\">, intervenes in the inflammatory process and manages to put a significant brake on it. The results are still preliminary, but they shed light on a previously unknown mechanism through which fine particulate matter could damage our airways. <\/span><\/p>\n<\/div>\n<div class=\"section related-news\">\n  <div id=\"relatedposts-block_5ec650d30e176\" class=\"news-row w-row\">\n      <div class=\"w-col w-col-4 w-col-stack\">\n      <a href=\"https:\/\/solongevity.com\/en\/longevity-news\/this-is-how-acute-inflammation-becomes-chronic\/\" class=\"news-thumbnail w-inline-block\">\n        <img decoding=\"async\" src=\"https:\/\/solongevity.com\/wp-content\/uploads\/2022\/11\/POST-29-03.10.2020.jpg\" alt=\"\" class=\"thumbnail-img\">\n        <div class=\"thumbnail-container\">\n          <div class=\"meta\">\n          News          <\/div>\n          <h2 class=\"heading-7\">This is how acute inflammation becomes chronic<\/h2>\n          <p>At least three mechanisms are known why acute inflammation can become chronic, accelerating aging. And there are foods that can lower inflammation, but be careful of so-called &#8220;anti-inflammatory diets&#8221; that are not based on science<\/p>\n        <\/div>\n        <div class=\"thumbnail-readmore-box\">\n          <p class=\"read-more\">Leggi l&#x27;articolo<\/p>\n        <\/div>\n      <\/a>\n    <\/div>\n      <div class=\"w-col w-col-4 w-col-stack\">\n      <a href=\"https:\/\/solongevity.com\/en\/longevity-news\/cellfasting-stimulating-sirtuins-with-a-nutraceutical\/\" class=\"news-thumbnail w-inline-block\">\n        <img decoding=\"async\" src=\"https:\/\/solongevity.com\/wp-content\/uploads\/2022\/11\/1_shutterstock_1820409992.jpeg\" alt=\"\" class=\"thumbnail-img\">\n        <div class=\"thumbnail-container\">\n          <div class=\"meta\">\n          CellFasting, News, Nutraceuticals          <\/div>\n          <h2 class=\"heading-7\">CellFasting, stimulating sirtuins with a nutraceutical<\/h2>\n          <p>Longevity genes can be activated with a specific mix of nutrients. This is what prompted SoLongevity research to develop a special formulation: a combination of amino acids, polydatin and NAC which, in a controlled clinical trial, proved effective in rebalancing oxidative stress and reducing inflammatory parameters.<\/p>\n        <\/div>\n        <div class=\"thumbnail-readmore-box\">\n          <p class=\"read-more\">Leggi l&#x27;articolo<\/p>\n        <\/div>\n      <\/a>\n    <\/div>\n    <\/div>\n<\/div>\n&#13;\n<p> <\/p>&#13;\n","protected":false},"excerpt":{"rendered":"<p>PM2.5 particulate matter lowers the levels of a protein, sirtuin 2, which regulates important physiological processes underlying airway inflammation. This is revealed by a study that also identifies a potential therapeutic avenue <\/p>\n","protected":false},"author":1,"featured_media":701,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[158,60],"tags":[160,172],"class_list":["post-40878","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en","category-old-posts","tag-active-ageing","tag-sirtuins"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Sirtuins, fine particulate matter, pollution and inflammation.<\/title>\n<meta name=\"description\" content=\"Sirtuin regulates physiological processes underlying airway inflammation. 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