{"id":40882,"date":"2022-05-13T15:39:25","date_gmt":"2022-05-13T15:39:25","guid":{"rendered":"https:\/\/solongevity.com\/longevity-news\/telomere-length-influences-the-risk-of-severe-covid\/"},"modified":"2026-11-03T15:59:47","modified_gmt":"2026-11-03T15:59:47","slug":"telomere-length-influences-the-risk-of-severe-covid","status":"publish","type":"post","link":"https:\/\/solongevity.com\/en\/longevity-news\/telomere-length-influences-the-risk-of-severe-covid\/","title":{"rendered":"Telomere Length Influences the Risk of Severe COVID"},"content":{"rendered":"<div id=\"title_text-block_623c6419c27ba\">\n          <p><strong>Article from 2022<\/strong><\/p>\n<p lang=\"it-IT\" align=\"LEFT\"><em>Telomere shortening, one of the \u201cmeasures\u201d of biological age, appears to be strongly correlated with the risk of COVID-19 mortality. In particular in women, and especially after age 65 <\/em><\/p>\n<p lang=\"it-IT\" align=\"LEFT\">\n<p><em><b>What this article is about<\/b><\/em><\/p>\n<ul>\n<li><em>Telomeres are the end portions of chromosomes, which shorten with each cell replication<\/em><\/li>\n<li><em>Telomere shortening is linked to various diseases of aging<\/em><\/li>\n<li><em>A new Spanish study confirms the association between telomere length and COVID-19 mortality, particularly significant for women over 65<\/em><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><em><b>Related articles<\/b><\/em><\/p>\n<ul>\n<li><em><a href=\"https:\/\/solongevity.com\/longevity-news\/covid-telomeri-e-danni-al-dna\/\" target=\"_blank\" rel=\"noopener\">COVID, telomeres and DNA damage<\/a><\/em><\/li>\n<li><em><a href=\"https:\/\/solongevity.com\/en\/longevity-news\/why-dowe-age-identify-9-biological-causes\/\" target=\"_blank\" rel=\"noopener\">Why do we age? 9 biological causes discovered <\/a><\/em><\/li>\n<li><em><a href=\"https:\/\/solongevity.com\/en\/longevity-news\/sirtuins-the-7-genes-that-make-us-live-longer-2\/\" target=\"_blank\" rel=\"noopener\">Sirtuins, the 7 genes that make us live longer and better<\/a><\/em><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"title_text-block_623c5db9c27b1\">\n          <p><strong>Telomeres<\/strong>, the \u201cend caps\u201d of <strong>chromosomes<\/strong> that shorten with advancing age, could provide valuable information on the risk of developing <strong>severe COVID-19<\/strong> infection. This is the claim of a study conducted by the <strong>Carlos III Health Institute<\/strong> in Madrid, which identified a significant association between the length of <strong>telomeres<\/strong> and <strong>COVID-19<\/strong> mortality. The effect mainly concerns women aged 65 and over. The research has just been presented at the <strong>European Congress of Clinical Microbiology and Infectious Diseases<\/strong> (ECCMID) in Lisbon, and the authors have published the study abstract (<a href=\"https:\/\/drive.google.com\/file\/d\/1vEGYI4gHcqkoSB_nB5BQVWar1laqxA_v\/view\">Relative telomere length impact on mortality and survival of COVID-19<\/a>).   <\/p>\n<\/div>\n<div id=\"title_text-block_623c5e4dc27b2\">\n        <h3 class=\"article-title\">Telomere length as an index of health<\/h3>\n          <p><strong>Telomeres<\/strong> are small portions of DNA located at the ends of <strong>chromosomes<\/strong>. They are a bit like indicators of the cell&#8217;s age (although they are not as precise as biological clocks): every time a <strong>cell divides<\/strong>, in fact, they <strong>shorten<\/strong>, until the point at which, when they are too worn, the cell no longer divides and, damaged, enters a phase called <strong>senescence<\/strong>. We have long known (<a href=\"https:\/\/www.nature.com\/articles\/s41556-022-00842-x\">Nature Cell Biology<\/a>) that the reduction in the length of these components is associated with numerous <strong>diseases<\/strong> typical of aging, from <strong>cancers<\/strong> to <strong>osteoarthritis<\/strong>, up to a higher risk of certain <strong>infections<\/strong>.  <\/p>\n<\/div>\n<div id=\"custom_quote-block_623c5e70c27b3\" class=\"quote\">\n  <p class=\"quote\"><em><strong>Short telomeres can be associated with various diseases of aging<\/strong><\/em>\n<\/p>\n<\/div>\n<div id=\"title_text-block_623c5e87c27b4\">\n        <h3 class=\"article-title\">Studying COVID-19<\/h3>\n          <p>Today the focus is on <strong>COVID<\/strong>: the researchers related the <strong>size<\/strong> <strong>of the<\/strong> <strong>telomeres<\/strong> to the severity of <strong>SARS-CoV-2<\/strong> infection in 608 patients hospitalized during the first wave of the pandemic, in 2020, and therefore not yet vaccinated. Telomere length was measured with blood tests carried out within 20 days of hospital admission. The authors then considered the weight of risk factors and individual characteristics, such as sex, age, smoking and the presence of other diseases. In the study, 75 hospitalized participants, with an average age of 78, died of COVID-19.   <\/p>\n<p><img fetchpriority=\"high\" fetchpriority=\"high\" decoding=\"async\" fetchpriority=\"high\" class=\"size-full wp-image-8797\" src=\"https:\/\/solongevity.com\/wp-content\/uploads\/2022\/11\/shutterstock_2085592342.jpg\" alt=\"Severe COVID-19: watch out for telomeres\" width=\"1000\" height=\"583\"> Telomeres are the end portions of chromosomes. Every time a cell divides they shorten, until the point at which, when they are too worn, the cell no longer divides and, damaged, enters a phase called senescence. <\/p>\n<\/div>\n<div id=\"title_text-block_623d9ea092112\">\n        <h3 class=\"article-title\">Shorter telomeres, higher risk<\/h3>\n          <p>The statistical results, spread over the entire sample, indicate that as <strong>telomere length<\/strong> decreases, <strong>COVID mortality<\/strong> increases significantly. Analyzing the phenomenon in a stratified way, that is, considering only certain categories of participants, it becomes clear that the effect detected concerns almost exclusively <strong>women<\/strong> and, among them, above all those over <strong>65<\/strong> &#8211; the majority, given that the average age of the overall sample is about 68. <\/p>\n<p>In female patients with <strong>longer telomeres<\/strong> \u2013 and therefore with less cellular aging than the others \u2013 the <strong>risk of dying<\/strong> within a month was <strong>70% lower<\/strong>, and 76% lower for dying within 3 months. Considering only participants <strong>over 65<\/strong>, the risk is <strong>about 80% lower<\/strong>. In men, by contrast, no significant association between telomeres and COVID severity was found.  <\/p>\n<\/div>\n<div id=\"custom_quote-block_623c5e9dc27b5\" class=\"quote\">\n  <p class=\"quote\"><em><strong>As telomere length decreases, COVID-19 mortality increases in women over 65<\/strong><\/em>\n<\/p>\n<\/div>\n<div id=\"title_text-block_623d9f1392113\">\n          <p>In <strong>older<\/strong> <strong>women<\/strong>, telomere length is a parameter that could be predictive of the likelihood of <strong>very severe COVID infections<\/strong>, as explained by <strong>Ana Virseda-Berdices<\/strong>, one of the study coordinators. In men, the lack of statistical significance of the effect could also be masked by other factors, according to the author. For example, it could be due to the presence of pre-existing diseases that worsen the situation in themselves, regardless of the level of cellular aging.  <\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"custom_quote-block_623c5f89c27b8\" class=\"quote\">\n  <p class=\"quote\"><em><strong>Telomere length could be predictive of severe COVID-19<\/strong><\/em>\n<\/p>\n<\/div>\n<div id=\"title_text-block_623c5f98c27b9\">\n        <h3 class=\"article-title\">It is not the first time<\/h3>\n          <p>The processes underlying this phenomenon are not yet known, but today&#8217;s work is not the only one to have highlighted it. There are already some studies, including an <a href=\"https:\/\/solongevity.com\/longevity-news\/covid-telomeri-e-danni-al-dna\/\" target=\"_blank\" rel=\"noopener\">Italian study<\/a> by <strong>IFOM<\/strong> in Milan and <strong>IGM-CNR<\/strong> in Pavia, that show an association between <strong>damage<\/strong> <strong>to<\/strong> <strong>telomeres<\/strong> and susceptibility to serious <strong>infections<\/strong> <strong>with<\/strong> <strong>SARS-CoV-2<\/strong>. <a href=\"https:\/\/www.embopress.org\/doi\/full\/10.15252\/embr.202153658\" target=\"_blank\" rel=\"noopener\">In the research<\/a> by IFOM and CNR, the proposed mechanism concerns <strong>the aging of certain lung cells<\/strong> \u2013 type II alveolar epithelial cells \u2013 which would thus become \u201ceasier targets\u201d and allow greater entry of the virus. <\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div class=\"section related-news\">\n  <div id=\"relatedposts-block_5ec650d30e176\" class=\"news-row w-row\">\n      <div class=\"w-col w-col-4 w-col-stack\">\n      <a href=\"https:\/\/solongevity.com\/en\/longevity-news\/long-covid-symptoms-of-early-immune-aging\/\" class=\"news-thumbnail w-inline-block\">\n        <img decoding=\"async\" src=\"https:\/\/solongevity.com\/wp-content\/uploads\/2022\/11\/A019_shutterstock_1910503963_2.png\" alt=\"\" class=\"thumbnail-img\">\n        <div class=\"thumbnail-container\">\n          <div class=\"meta\">\n          News, Scientific study          <\/div>\n          <h2 class=\"heading-7\">What&#8217;s Long Covid<\/h2>\n          <p>According to some clinical observations, the immune system of young Covid-19 survivors appears to age prematurely, contributing to the onset of Long Covid. But this ageing process could also be reversed <\/p>\n        <\/div>\n        <div class=\"thumbnail-readmore-box\">\n          <p class=\"read-more\">Leggi l&#x27;articolo<\/p>\n        <\/div>\n      <\/a>\n    <\/div>\n      <div class=\"w-col w-col-4 w-col-stack\">\n      <a href=\"https:\/\/solongevity.com\/en\/longevity-news\/longevity-diagnostics-what-it-is-and-why-it-matters\/\" class=\"news-thumbnail w-inline-block\">\n        <img decoding=\"async\" src=\"https:\/\/solongevity.com\/wp-content\/uploads\/2022\/11\/shutterstock_1463056853-1-scaled29183425.jpg\" alt=\"\" class=\"thumbnail-img\">\n        <div class=\"thumbnail-container\">\n          <div class=\"meta\">\n          News, Scientific study          <\/div>\n          <h2 class=\"heading-7\">Longevity Diagnostics: What It Is and Why It Matters<\/h2>\n          <p>Measuring one\u2019s state of health against an ideal aging process allows us to understand how well we are able to preserve our physical and mental performance and how exposed we are to future risks of chronic diseases\r\n<\/p>\n        <\/div>\n        <div class=\"thumbnail-readmore-box\">\n          <p class=\"read-more\">Leggi l&#x27;articolo<\/p>\n        <\/div>\n      <\/a>\n    <\/div>\n    <\/div>\n<\/div>\n&#13;\n<p> <\/p>&#13;\n","protected":false},"excerpt":{"rendered":"<p>One of the measures of biological age, telomere length, could predict the risk of developing severe forms of COVID-19. The finding applies above all to women over 65 <\/p>\n","protected":false},"author":1,"featured_media":1147,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[158,60],"tags":[160,164],"class_list":["post-40882","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en","category-old-posts","tag-active-ageing","tag-covid-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Telomere Length Influences the Risk of Severe COVID<\/title>\n<meta name=\"description\" content=\"Telomere shortening, one of the \u201cmeasures\u201d of biological age, appears to be strongly correlated with the risk of COVID-19 mortality.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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