{"id":40888,"date":"2022-01-26T17:10:39","date_gmt":"2022-01-26T17:10:39","guid":{"rendered":"https:\/\/solongevity.com\/longevity-news\/getting-2-years-younger-in-8-weeks-the-recipe-for-turning-back-the-hands-of-the-biological-clock\/"},"modified":"2026-10-19T15:09:56","modified_gmt":"2026-10-19T15:09:56","slug":"inflammatory-clock-immune-age","status":"publish","type":"post","link":"https:\/\/solongevity.com\/en\/longevity-news\/inflammatory-clock-immune-age\/","title":{"rendered":"Getting 2 Years Younger in 8 Weeks: The Recipe for Turning Back the Hands of the Biological Clock"},"content":{"rendered":"<div id=\"title_text-block_618e372ecd2cd\">\n          <p><em>When it comes to cardiovascular disease, the age of the immune system matters more than chronological age. Today the iAge \u201cinflammatory clock\u201d makes it possible to estimate it. How does it work?  <\/em><\/p>\n<p><strong><em>What you will find in this article<\/em><\/strong><\/p>\n<ul>\n<li><em>there is a test to estimate immune age: iAge<\/em><\/li>\n<li><em>the inflammatory score can indicate the immune response and the risk of aging-related diseases<\/em><\/li>\n<li><em>a study in Bologna identifies supercentenarians with the inflammatory age of a 25-year-old<\/em><\/li>\n<li><em>the cytokine CXCL9 is a biomarker for cardiovascular disease<\/em><\/li>\n<\/ul>\n<p><strong><em>Other topics you may be interested in<\/em><\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/solongevity.com\/en\/longevity-news\/this-is-how-acute-inflammation-becomes-chronic\/\"><em>This is how <\/em><em>acute inflammation becomes chronic<\/em> <\/a><\/li>\n<li><a href=\"https:\/\/solongevity.com\/en\/longevity-news\/long-covid-syndrome-2\/\"><em>Long COVID syndrome? <\/em><\/a><\/li>\n<li><a href=\"https:\/\/solongevity.com\/en\/longevity-news\/foods-and-diet-to-stimulate-the-sirtuins\/\"><em>Sirtuins: &#8220;Sirt&#8221; foods, diet and recipes<\/em><\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"title_text-block_5eb51701a3d3e\">\n        <h3 class=\"article-title\">Immune age<\/h3>\n          <p><span style=\"font-weight: 400\">How much are we at <\/span><b>risk<\/b><span style=\"font-weight: 400\"> of <\/span><b>chronic diseases<\/b><span style=\"font-weight: 400\">? More than chronological age, what matters is the age of the immune system. A research group from Stanford University and the Buck Institute for Research on Aging has developed a tool to estimate our   <\/span><b>immune age<\/b><span style=\"font-weight: 400\">, an \u201c<\/span><b>inflammatory clock<\/b><span style=\"font-weight: 400\">\u201d, which is based on a series of parameters of the <\/span><b>inflammation <\/b><span style=\"font-weight: 400\">linked to <\/span><b>aging<\/b><span style=\"font-weight: 400\">. Obtained thanks to an algorithm of <\/span><b>artificial intelligence<\/b><span style=\"font-weight: 400\">, the new clock is called <\/span><b>iAge<\/b><span style=\"font-weight: 400\"> and was presented in a <\/span><a href=\"https:\/\/www.nature.com\/articles\/s43587-021-00082-y\"><span style=\"font-weight: 400\">paper<\/span> <span style=\"font-weight: 400\">published in <\/span><i><span style=\"font-weight: 400\">Nature Aging<\/span><\/i><\/a><span style=\"font-weight: 400\">.<\/span> <\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"title_text-block_60d6f269ec137\">\n        <h3 class=\"article-title\">Studying the immune system<\/h3>\n          <p><span style=\"font-weight: 400\">The researchers studied the blood tests of about <\/span><b>1,000 volunteers of various ages<\/b><span style=\"font-weight: 400\">, including many older adults, taking part in the <\/span><i><span style=\"font-weight: 400\">Immunome<\/span><\/i><span style=\"font-weight: 400\">. The analyses, carried out in 2010, assessed the levels of certain <\/span><b>cytokines<\/b><span style=\"font-weight: 400\">, that is, molecules produced when there is inflammation (the same ones also generated in excess in patients with severe COVID-19). The parameters also included the concentration of various types of  <\/span><b>immune cells<\/b><span style=\"font-weight: 400\"> and the overall <\/span><b>activity<\/b><span style=\"font-weight: 400\"> of thousands of <\/span><b>genes<\/b><span style=\"font-weight: 400\"> within these cells.<\/span><\/p>\n<\/div>\n<div id=\"custom_quote-block_616c44e2a59ef\" class=\"quote\">\n  <p class=\"quote\"><b><i>The inflammatory clock is based on a series of parameters of aging-related inflammation<\/i><\/b>\n&nbsp;\n<\/p>\n<\/div>\n<div id=\"title_text-block_60fa9a61d915b\">\n          <p><span style=\"font-weight: 400\">The aim was to <\/span><b>quantify inflammation<\/b><span style=\"font-weight: 400\">, an inflammation that is <\/span><b>not good<\/b><span style=\"font-weight: 400\"> which tends to increase over time and is not necessarily aligned with chronological age. The authors then compared the blood values collected years earlier with certain health parameters and the presence of diseases, and examined the impact of inflammation on  <\/span><b>mortality<\/b><span style=\"font-weight: 400\">, validating the results against data from other samples under study. They also included data from an ongoing study in Bologna, which includes a group of exceptionally long-lived people. <\/span><\/p>\n<p><img fetchpriority=\"high\" fetchpriority=\"high\" decoding=\"async\" fetchpriority=\"high\" class=\"wp-image-4345 size-full\" src=\"https:\/\/solongevity.com\/wp-content\/uploads\/2022\/11\/shutterstock_754768255_img2.jpeg\" alt=\"Immune age and older adults\" width=\"1000\" height=\"667\"> Some studies on the oldest old confirm that chronological age and immune age do not always correspond<\/p>\n<\/div>\n<div id=\"title_text-block_5eb51812a3d42\">\n        <h3 class=\"article-title\">The inflammatory clock<\/h3>\n          <p><span style=\"font-weight: 400\">The data were then combined and processed using an <\/span><b>artificial intelligence (AI)<\/b><span style=\"font-weight: 400\">. AI made it possible to create the \u201cinflammatory clock\u201d, which suggests the<\/span><b>immune age<\/b><span style=\"font-weight: 400\">. In the architecture of the inflammatory clock, the levels of 50 cytokines are decisive; their values, processed by the algorithm, returned the <\/span><b>inflammatory score <\/b><span style=\"font-weight: 400\">associated both with the immune response and with the person&#8217;s risk of developing numerous <\/span><b>aging-related diseases<\/b><span style=\"font-weight: 400\">.<\/span> <\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"custom_quote-block_6151a36c58aa0\" class=\"quote\">\n  <p class=\"quote\"><b><i>Artificial intelligence quantifies \u201cbad\u201d inflammation and returns a score indicative of immune age<\/i><\/b>\n<\/p>\n<\/div>\n&#13;\n<p> <\/p>&#13;\n<div id=\"title_text-block_613dde0b49802\">\n          <p><span style=\"font-weight: 400\">The model <\/span><b>works<\/b><span style=\"font-weight: 400\">: blood tests on the oldest old in Bologna showed that their inflammatory age was on average 40 years lower, and one supercentenarian had an inflammatory age of 25.<\/span><\/p>\n<p><span style=\"font-weight: 400\">The authors found that among the substances central to estimating the age of the immune system is a protein, the <\/span><b>cytokine CXCL9<\/b><span style=\"font-weight: 400\">, which attracts immune cells to the site of an infection and which shows a <\/span><b>sharp increase after age 60<\/b><span style=\"font-weight: 400\">.<\/span><\/p>\n<\/div>\n<div id=\"custom_quote-block_6151a4b5f367c\" class=\"quote\">\n  <p class=\"quote\"><b><i>Immune age is not always aligned with a person&#8217;s chronological age<\/i><\/b>\n<\/p>\n<\/div>\n<div id=\"title_text-block_6151a4e1f367d\">\n        <h3 class=\"article-title\">Watch out for the heart and more<\/h3>\n          <p><span style=\"font-weight: 400\">This cytokine, produced not only by the immune system but also by the endothelial cells lining the inner walls of blood vessels, plays a role in various <\/span><b>cardiovascular diseases<\/b><span style=\"font-weight: 400\">.<\/span> <\/p>\n<\/div>\n<div id=\"title_text-block_6151a4fdf367e\">\n          <p><span style=\"font-weight: 400\">A further analysis of a subsample of almost 100 participants showed that <\/span><b>high concentrations <\/b><span style=\"font-weight: 400\">of the cytokine CXCL9 and of the other inflammatory molecules are linked to a <\/span><b>higher risk<\/b><span style=\"font-weight: 400\"> of certain diseases. In particular, there is increased  <\/span><b>arterial stiffness<\/b><span style=\"font-weight: 400\">, which in turn is associated with a higher risk of <\/span><b>heart attack<\/b><span style=\"font-weight: 400\">, <\/span><b>stroke<\/b><span style=\"font-weight: 400\"> and <\/span><b>kidney failure<\/b><span style=\"font-weight: 400\">, and a <\/span><b>thickening of the left ventricular wall.<\/b><span style=\"font-weight: 400\"> <\/span><\/p>\n<p><span style=\"font-weight: 400\">Studies in animal models have also reported that lowering CXCL9 levels could also restore proper functioning of endothelial cells, which would become younger again.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" class=\"wp-image-4349 size-full\" src=\"https:\/\/solongevity.com\/wp-content\/uploads\/2022\/11\/shutterstock_1723725676_img3.jpeg\" alt=\"\" width=\"1000\" height=\"667\"> The cytokine CXCL9 seems to be a biomarker for the risk of cardiovascular disease: the higher its concentration, the greater the risk<\/p>\n<p><span style=\"font-weight: 400\"> <\/span><span style=\"font-weight: 400\">The research is still in its early stages, but it opens a path to better understanding why some people develop chronic diseases more easily than others. The goal is to be able to  <\/span><b>assess individual risk<\/b><span style=\"font-weight: 400\"> and <\/span><b>recognize in advance<\/b><span style=\"font-weight: 400\"> any conditions or disorders that may worsen over time, in order to <\/span><b>treat them early<\/b><span style=\"font-weight: 400\">.<\/span><\/p>\n<\/div>\n    <\/div>\n<div id=\"call_to_action-block_60fbebe99689a\" class=\"section article-footer biblio\">\n  <div>\n  <h3>Bibliography<\/h3>\n    <p><i><span style=\"font-weight: 400\">Nature Aging : <\/span><\/i>https:\/\/www.nature.com\/articles\/s43587-021-00082-y<\/p>\n<p>&nbsp;<\/p>\n  <\/div>\n<\/div>\n<div class=\"section related-news\">\n  <div id=\"relatedposts-block_5ec650d30e176\" class=\"news-row w-row\">\n      <div class=\"w-col w-col-4 w-col-stack\">\n      <a href=\"https:\/\/solongevity.com\/en\/longevity-news\/longevity-diagnostics-what-it-is-and-why-it-matters\/\" class=\"news-thumbnail w-inline-block\">\n        <img decoding=\"async\" src=\"https:\/\/solongevity.com\/wp-content\/uploads\/2022\/11\/shutterstock_1463056853-1-scaled29183425.jpg\" alt=\"\" class=\"thumbnail-img\">\n        <div class=\"thumbnail-container\">\n          <div class=\"meta\">\n          News, Scientific study          <\/div>\n          <h2 class=\"heading-7\">Longevity Diagnostics: What It Is and Why It Matters<\/h2>\n          <p>Measuring one\u2019s state of health against an ideal aging process allows us to understand how well we are able to preserve our physical and mental performance and how exposed we are to future risks of chronic diseases\r\n<\/p>\n        <\/div>\n        <div class=\"thumbnail-readmore-box\">\n          <p class=\"read-more\">Leggi l&#x27;articolo<\/p>\n        <\/div>\n      <\/a>\n    <\/div>\n    <\/div>\n<\/div>\n    <\/div>\n<div id=\"call_to_action-block_5ed103a4924fd\" class=\"cta-section\">\n  <h1 class=\"section-news-title\" data-ix=\"fadein\">Would you like more information and details about the Age360 Program?<\/h1>\n  <a href=\"https:\/\/solongevity.com\/contact-us\/\" target=\"\" class=\"button white w-button\">Contact us <\/a>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>When it comes to cardiovascular disease, the age of the immune system matters more than chronological age. Today the iAge \u201cinflammatory clock\u201d makes it possible to estimate it. How does it work?  <\/p>\n","protected":false},"author":1,"featured_media":700,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[158,60],"tags":[162,159,170],"class_list":["post-40888","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en","category-old-posts","tag-biological-age","tag-longevity-science-en","tag-prevention"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The risk of disease? Your \u201cinflammatory clock\u201d tells you<\/title>\n<meta name=\"description\" content=\"When it comes to cardiovascular disease, the age of the immune system matters more than chronological age. 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Your \u201cinflammatory clock\u201d tells you","description":"When it comes to cardiovascular disease, the age of the immune system matters more than chronological age. How can the inflammatory clock be measured?","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/solongevity.com\/en\/longevity-news\/inflammatory-clock-immune-age\/","og_locale":"en_US","og_type":"article","og_title":"The risk of disease? Your \u201cinflammatory clock\u201d tells you","og_description":"When it comes to cardiovascular disease, the age of the immune system matters more than chronological age. 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Your \u201cinflammatory clock\u201d tells you","isPartOf":{"@id":"https:\/\/solongevity.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/solongevity.com\/en\/longevity-news\/inflammatory-clock-immune-age\/#primaryimage"},"image":{"@id":"https:\/\/solongevity.com\/en\/longevity-news\/inflammatory-clock-immune-age\/#primaryimage"},"thumbnailUrl":"https:\/\/solongevity.com\/wp-content\/uploads\/2022\/11\/shutterstock_308543876.jpeg","datePublished":"2022-01-26T17:10:39+00:00","dateModified":"2026-10-19T15:09:56+00:00","description":"When it comes to cardiovascular disease, the age of the immune system matters more than chronological age. 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