{"id":4311,"date":"2021-11-01T20:22:20","date_gmt":"2021-11-01T20:22:20","guid":{"rendered":"https:\/\/solongevity.com\/?p=4311"},"modified":"2023-08-19T17:59:19","modified_gmt":"2023-08-19T17:59:19","slug":"the-risk-of-disease-dice-your-clock-inflammatory","status":"publish","type":"post","link":"https:\/\/solongevity.com\/en\/longevity-news\/the-risk-of-disease-dice-your-clock-inflammatory\/","title":{"rendered":"The risk of disease? Your inflammatory clock tells you"},"content":{"rendered":"
\n How much are we at <\/span>risk of chronic diseases<\/b>? \u00a0Our immune system age is more important than our chronological age. A research team from Stanford University and the Buck Institute for Research on Aging have developed a tool to estimate our <\/span>immune age<\/b>, an <\/span>‘inflammatory clock’<\/b>, leveraging on a number of <\/span>age-related inflammation <\/b>parameters. Based on an\u00a0<\/span>artificial intelligence <\/b>algorithm, the new clock is called iAge and was presented in a\u00a0 <\/span>paper published in Nature Aging<\/span><\/a>. <\/span><\/div>\n\r\n\r\n
\n

Studying the immune system<\/h3>\n The researchers studied the blood tests of about <\/span>1000 volunteers of various age-groups<\/b>, including many elderly people, participating in the <\/span>Immunome<\/span><\/i> project. The analyses, carried out in 2010, assessed the levels of certain <\/span>cytokines<\/b>, aka molecules produced by an inflammation status (the same molecules are also excessively generated in patients with severe Covid-19). Among the studied parameters, The concentration of different types of <\/span>immune cells<\/b> and their genetic activity <\/span>have been included.<\/span><\/div>\n\r\n\r\n
\n

The inflammatory clock is based on several parameters of age-related inflammation<\/i><\/b><\/p>\n<\/div>\n\r\n\r\n

\n The main goal was on <\/span>quantifying inflammation<\/b>, <\/span>not the good one, <\/b>that tends to increase over time and is not necessarily aligned with age. Next, the authors compared blood values collected years earlier with certain parameters of health status<\/em>, the presence of diseas<\/em>e, and on <\/span>mortality<\/strong><\/em>.<\/strong><\/em> They cross-validated the results with data from other clinical studies\u2019 blood samples. Among them, the ones owned by an ongoing study in Bologna (Italy) on <\/span>centenarians<\/span><\/i>.<\/span>\r\n\r\n\"Et\u00e0 Alcuni studi sui grandi anziani confermano che non sempre l’et\u00e0 anagrafica e quella immunitaria corrispondono<\/div>\n\r\n\r\n
\n

The inflammatory clock<\/h3>\n All data have been then combined and reprocessed by using an <\/span>artificial intelligence (AI) <\/b>algorithm. The AI was able to create the ‘inflammatory clock’, which suggests <\/span>immune age<\/b>. The architecture core of the inflammatory clock is based upon the levels of 50 cytokines; the algorithm was able to process their specific values and provide the <\/span>inflammatory score<\/b> associated with the <\/span>immune response capability<\/b> and the individual risk of developing several <\/span>age-related diseases<\/b>. <\/span><\/div>\n\r\n\r\n
\n

Artificial intelligence quantifies ‘bad’ inflammation and returns an Immune-Age score<\/i><\/b><\/p>\n<\/div>\n\r\n\r\n\r\n

 <\/p>\r\n\r\n\r\n

\n The model works<\/b>: in Bologna, the centenarians\u2019 blood tests showed that their average Immune-Age was 40 years younger than regular folks, and the ultra-centenarians (beyond 110 y.o.) had an Immune-age of a 25 years person.<\/span>\r\n\r\nThe authors discovered that the <\/span>cytokine CXCL9 level<\/b> is the leading factor across all the immune-system parameters, this protein is strongly linked to infections and dramatically increases <\/span>after the age of 60<\/b>.<\/span><\/div>\n\r\n\r\n
\n

Immune age is not always aligned with a person’s age<\/i><\/b><\/p>\n<\/div>\n\r\n\r\n

\n

Beware of the heart and beyond<\/h3>\n This specific cytokine, produced not only by the immune system but also by the blood vessels\u2019 endothelial cells, plays a role in various <\/span>cardiovascular diseases<\/b>. <\/span><\/div>\n\r\n\r\n
\n Further analysis of a subsample of almost 100 participants showed that <\/span>high concentrations <\/b>of the cytokine CXCL9 and other inflammatory molecules exposed to an<\/span> increased risk <\/b>of certain diseases. In particular, it has been discovered that it increases <\/span>arterial stiffness<\/b>, associated with an increased risk of <\/span>heart attack, stroke and kidney failure, and an enlarged left ventricular wall<\/b>. <\/span>\r\n\r\nStudies in animal models have also shown that lowering CXCL9 levels could also restore proper functioning of endothelial cells, which would become younger again.<\/span>\r\n\r\n \r\n\r\n\"\" La citochina CXCL9 sembra essere un biomarcatore per il rischio di patologie cardiovascolari: pi\u00f9 \u00e8 alta la sua concentrazione, maggiore \u00e8 il rischio\r\n\r\nThe research is still at the starting blocks, but it opens to a better way of understanding why some people develop chronic diseases more easily than others. The aim is to be able to <\/span>assess individual risk and recognise in advance<\/b> any conditions or disorders that may worsen over time, in order to <\/span>treat them early<\/b>.<\/span><\/div>\n\r\n\r\n <\/div>\n
\n
\n

Bibliography<\/h3>\n Nature Aging : <\/span><\/i>https:\/\/www.nature.com\/articles\/s43587-021-00082-y <\/div>\n<\/div>\n\r\n\r\n
\n
\n
\n \n \"\"\n
\n
\n News <\/div>\n

The risk of disease? Your inflammatory clock tells you<\/h2>\n

When it comes to cardiovascular disease, the age of our immune system matters more than age. Today, the iAge “inflammatory clock” allows us to estimate it. How does it work? <\/p>\n <\/div>\n

\n

Leggi l'articolo<\/p>\n <\/div>\n <\/a>\n <\/div>\n

\n \n \"\"\n
\n
\n News <\/div>\n

The risk of disease? Your inflammatory clock tells you<\/h2>\n

When it comes to cardiovascular disease, the age of our immune system matters more than age. Today, the iAge “inflammatory clock” allows us to estimate it. How does it work? <\/p>\n <\/div>\n

\n

Leggi l'articolo<\/p>\n <\/div>\n <\/a>\n <\/div>\n

\n \n \"\"\n
\n
\n News <\/div>\n

The risk of disease? Your inflammatory clock tells you<\/h2>\n

When it comes to cardiovascular disease, the age of our immune system matters more than age. Today, the iAge “inflammatory clock” allows us to estimate it. How does it work? <\/p>\n <\/div>\n

\n

Leggi l'articolo<\/p>\n <\/div>\n <\/a>\n <\/div>\n <\/div>\n<\/div>\n\r\n\r\n\r\n

 <\/p>\r\n","protected":false},"excerpt":{"rendered":"

When it comes to cardiovascular disease, the age of our immune system matters more than age. Today, the iAge “inflammatory clock” allows us to estimate it. How does it work? <\/p>\n","protected":false},"author":1,"featured_media":28,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[158,60],"tags":[162,159,170],"class_list":["post-4311","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en","category-old-posts","tag-biological-age","tag-longevity-science-en","tag-prevention"],"acf":[],"yoast_head":"\nThe risk of disease? Your 'inflammatory clock' tells you<\/title>\n<meta name=\"description\" content=\"When it comes to cardiovascular diseases, our immune system age matters more than our chronological age. 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