SoLongevity Nutraceuticals

The word nutraceuticals comes from the contraction of the words nutrition and pharmaceuticals.

Nutraceuticals are dietary supplements that have proven efficacy with respect to certain physiological processes, promoting their proper performance. By way of example, they can stimulate the insulin pathway or the protein pathway, they can help the production of muscle fiber or the production of certain components of the immune system. They cannot have a curative claim, like a drug, because that would bring them under the legislation and regulations of the latter category. This definition is not recognized by European law, which distinguishes only between dietary supplements, which can neither cure nor prevent, and drugs. The U.S. law, while replicating the old continent’s guideline, recognizes the possibility of supplements to improve certain physiological processes and not only to provide deficient nutritional principles.

In biochemistry, a Precursor is a molecule that is useful in the formation of another molecule, simplifying we can say that it is a component that can be used to produce another. Precursors can have very different characteristics from those of the molecule they can help form. These differences can be very useful in nutraceutical science. As an example, Resveratrol, an extremely potent molecule in the area of longevity, does not have the ability to cross the cell barrier in its pure form, whereas in the glycosylated form it is able to cross it and reach the heart of the cell releasing its beneficial potential. One of the glycosylated forms is Politadin, which is therefore called the precursor of Resveratrol.
In the cosmetic field, Retinol is well known, which is an inactive form of Vit. A until it is transformed into retinoic acid through interactions with a number of proteins at the dermal level.

Our formulas follow a path of scientific and clinical validation before being released to the market.

Once the formula is engineered, we test its efficacy in the laboratory with an in vitro study, that is, in cell models to verify an initial level of efficacy.

Then, the formula is produced in small quantities and tested on a small group of subjects, without any particular disease, for a period of 2-3 months. Targeted tests are done on these subjects to show whether the results obtained in the laboratory (in vitro) are confirmed on the person (in vivo).

With these results we design the clinical trial, similar to that of a drug, but different in duration (3 months) and type of diagnostics, in fact we do not measure the impact on diseases but the impact on physiological imbalances that we are interested in and that the scientific literature associates with the onset conditions of some chronic diseases.

The latter type of validation is carried out in the hospital setting, by a third party to SoLongevity, and ensures the total impartiality of the results.

Bioaccessibility is the noble portion of the food, which is the fraction of the food that is useful for metabolic/nutritional purposes and is released by digestive action to be absorbed by the intestinal tract.

Bioavailability is that % of the nutrient that manages to be absorbed by the body and reaches the circulatory stream for systemic utilization.

Once it reaches the bloodstream, the nutritional principle must be able to perform its function on a biological tissue or living organism. This functional capacity determines whether or not it can make a metabolic contribution.

For it to be able to perform this function, the nutritional principle must survive a series of biochemical reactions at the liver level (inhibitors) and barriers (i.e., cellular barrier) to get to release its contribution where it is needed.

After this long metabolic journey, the nutrient must arrive in a correct amount and form for the cellular system. Excesses of Vitamins and Nutrients can be as harmful as their deficiency.

The design of a dietary supplement must take into account all these dimensions in order to make a useful contribution to human metabolism and the different physiological targets it is intended to achieve.

All of our products are made in Italy by licensed manufacturers who control the entire production process and certify the origin of the ingredients.

They are cruelty free and not tested on animals.