CellFasting, stimulating sirtuins with a nutraceutical

Article by Solongevity Research
Longevity genes can be activated with a specific mix of nutrients. This is what prompted SoLongevity research to develop a special formulation: a combination of amino acids, polydatin and NAC which, in a controlled clinical trial, proved effective in rebalancing oxidative stress and reducing inflammatory parameters.

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Sirtuins

Sirtuins are the ‘Holy Grail’ of longevity science. It is therefore not surprising that many research groups have been studying them for years, investigating different ways of activating the genes underlying their synthesis, with the aim of maintaining or improving people’s health and enabling them to live well for a long time. How? Through food supplementation, for example. Thanks to SoLongevity research, a nutraceutical has been developed which exploits one of the mechanisms that activates sirtuins: CellFasting. Its formula is a combination of amino acids, polydatin and NAC which, in a controlled clinical trial, proved effective in rebalancing oxidative stress and reducing inflammatory parameters.

Sirtuins, what are they?

Sirtuins are proteins produced by a family of genes that all living beings possess and that have an extraordinarily simple and fascinating purpose: to ensure the survival of the organism. A sort of control room that turns on and off our metabolic activity and a series of biochemical processes that are essential to enable us to cope with extreme threats until optimal conditions are restored.  The science of longevity studies them because the possibility of activating them allows us to trigger a process of ‘resetting’ our organism: a bit like when your computer crashes and you have to press a combination of keys to restart it and make it work well again. We know that the pillars for stimulating them – in particular for stimulating Sirt1 – are simple: hunger, cold and physical risk. This is why certain longevity-promoting therapies focus on calorie restriction, cryotherapy and physical activity as emulation of a physical risk condition.

There are three ways to stimulate sirtuins: hunger, cold and physical risk

Sirt1 and calorie restriction

Within the sirtuin family, Sirt1 appears to be the one that governs cellular metabolism. It is activated when the cell perceives a nutritional deficiency because there is a lack of nutrients for both energetic (catabolic) and productive (anabolic) activity. It is as if the cell factory were suffering from a lack of fuel and raw materials to produce its products. Mimicking restriction is one way of tricking the body into activating sirtuin genes

The science of longevity studies sirtuins because the possibility of activating them makes it possible to trigger a process of “resetting” our organism

When the body registers this condition, it activates a specific metabolic pathway called AMPK. This set of biochemical reactions has the task of modulating the cell’s energy centre (the insulin pathway) and protein production activity (the mTOR pathway). If AMPK is activated, it progressively reduces cellular activity, keeping it to a minimum to the point of a sort of hibernation. The cell thus reduces its ‘wear and tear’ and ‘lasts’ longer.  Calorie restriction is therefore one of the ways of activating sirtuins (particularly Sirt1) because it ‘switches off’ cell activity, particularly when it is ‘over-revved’, i.e. over-stimulated by a high-calorie diet.

Nutraceutical strategy to stimulate sirtuins

In the world of food supplements, there are several which aim to modulate glucose levels to modulate the insulin pathway, linked to the transformation of glucose into energy. There is a second strategy, still experimental, which aims to directly reduce protein production activity (the mTor pathway). And finally, there is also a third approach which focuses on the AMPK modulator pathway, through the stimulation of sirtuins.

Calorie restriction is therefore one of the ways of activating sirtuins, particularly Sirt1, because it ‘shuts down’ cellular activity, especially when it is ‘over-revved’, i.e. over-stimulated by a high-calorie diet

Solongevity’s nutraceutical research has developed this latest strategy and devised a formula capable of stimulating the AMPK regulatory pathway through a very simple mechanism: make the cell believe it is in a condition of caloric restriction.   In our case, we make the cell believe it is in a situation of caloric restriction in order to activate the minimisation of its operating regime (Sirtuin ⇒ AMPK ⇒ cellular metabolism reduction).   SoLongevity’s research on sirtuins has led to the development of a nutraceutical that has been shown to balance oxidative stress and reduce inflammation This mechanism entails a series of possible benefits that Solongevity is still partly studying: some have emerged from an observational point of view, i.e. from use in specific pre-pathological conditions, suggesting areas of application to be explored in order to understand the cause-effect relationships; others from the deduction that comes from the scientific literature. All the benefits to be declared will have to be measured in dedicated clinical studies. To date, the formula developed by Solongevity as a “mimetic of caloric restriction” has led to the development of a product which we have called, not by chance, CellFasting This is not a meal replacement, nor a slimming product, but a nutraceutical which, together with a correct lifestyle and diet, helps to rebalance oxidative stress and reduce inflammatory parameters. Thanks to the combination of amino acids, polydatin and Acetylcysteine (NAC), CellFasting acts both as an anti-oxidant and by supporting energy metabolism, also reducing the sense of fatigue and tiredness.

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