Longevity genes can be activated with a specific mix of nutrients. This is what prompted SoLongevity research to develop a special formulation: a combination of amino acidsAmino acids are the basic substances that make up proteins. Each protein is characterized by a precise sequence of amino acid "bricks". Some are produced by the body by processing food, others, which the body cannot synthesize, must be taken directly with food., polydatin and NAC which, in a controlled clinical trial, proved effective in rebalancing oxidative stress and reducing inflammatory parameters.
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Sirtuins
SirtuinsSirtuins are proteins expressed by SIRT genes that perform an enzymatic activity, which means they stimulate chemical reactions essential for the body. Their function has been ascertained by several studies, although there still seems to be a lot to know about them. SIRTs in short:• are proteins with enzymatic properties
• regulate the metabolic processes related to insulin resistance
• have a control over immunity
• have a fundamental role in epigenetics
• are involved in defences against cancer
are the ‘Holy Grail’ of longevity science. It is therefore not surprising that many research groups have been studying them for years, investigating different ways of activating the genes underlying their synthesis, with the aim of maintaining or improving people’s health and enabling them to live well for a long time. How? Through food supplementation, for example. Thanks to SoLongevity research, a nutraceuticalNutraceutical is a syncratic neologism from "nutrition" and "pharmaceutical" coined by Stephen de Felice in 1989. Nutraceuticals are those nutrients contained in foods that have beneficial effects on health, their effectiveness has been proven by clinical trials. has been developed which exploits one of the mechanisms that activates sirtuins: CellFasting. Its formula is a combination of amino acids, polydatin and NAC which, in a controlled clinical trial, proved effective in rebalancing oxidative stress and reducing inflammatory parameters.
Sirtuins, what are they?
Sirtuins are proteins produced by a family of genes that all living beings possess and that have an extraordinarily simple and fascinating purpose: to ensure the survival of the organism. A sort of control room that turns on and off our metabolic activity and a series of biochemical processes that are essential to enable us to cope with extreme threats until optimal conditions are restored. The science of longevity studies them because the possibility of activating them allows us to trigger a process of ‘resetting’ our organism: a bit like when your computer crashes and you have to press a combination of keys to restart it and make it work well again.We know that the pillars for stimulating them – in particular for stimulating Sirt1 – are simple: hunger, cold and physical risk. This is why certain longevity-promoting therapies focus on calorie restriction, cryotherapy and physical activity as emulation of a physical risk condition.There are three ways to stimulate sirtuins: hunger, cold and physical risk
Sirt1 and calorie restriction
Within the sirtuin family, Sirt1 appears to be the one that governs cellular metabolism. It is activated when the cell perceives a nutritional deficiency because there is a lack of nutrients for both energetic (catabolic) and productive (anabolic) activity. It is as if the cell factory were suffering from a lack of fuel and raw materials to produce its products.
Mimicking restriction is one way of tricking the body into activating sirtuin genesThe science of longevity studies sirtuins because the possibility of activating them makes it possible to trigger a process of “resetting” our organism
When the body registers this condition, it activates a specific metabolic pathway called AMPKAMPK (AMP-activated protein kinase) stands for monophosphate-activated adenosine protein kinase. It is an enzyme that plays a critical role in cellular homeostasis and a signaller of the body's energy level: it signals whether there is enough in the body to activate cellular functions such as glucose absorption, fat oxidation, and the formation of new mitochondria. In case the energy is not enough, it stops the activity of creation of macro-molecules by pausing the production activity. The AMPK way is a "metabolic regulator".. This set of biochemical reactions has the task of modulating the cell’s energy centre (the insulinHormone produced by Langerhans island cells of the pancreas. It stimulates the entry of glucose into the cells, subtracting it from the blood and thus lowering blood sugar. It induces the use of glucose both to produce energy and for the synthesis of glycogen and fats. pathway) and protein production activity (the mTORThe mTOR (mammalian target of rapamycin) is a set of enzymes (route) that react to food-nutrients, breaking them down and recombining them to build new proteins useful for the "growth of the body". They react to specific hormonal stimuli (Insulin and IGF-1) thus becoming the center of control of growth and cell proliferation in metabolism. This metabolic route is also responsible for the elimination of old and defective cells (Cellular Autophagy) with the double advantage of recycling the fundamental components to produce new cells and eliminate them to prevent them from triggering degenerative and inflammatory processes. pathway). If AMPK is activated, it progressively reduces cellular activity, keeping it to a minimum to the point of a sort of hibernation. The cell thus reduces its ‘wear and tear’ and ‘lasts’ longer. Calorie restriction is therefore one of the ways of activating sirtuins (particularly Sirt1) because it ‘switches off’ cell activity, particularly when it is ‘over-revved’, i.e. over-stimulated by a high-calorie diet.
Nutraceutical strategy to stimulate sirtuins
In the world of food supplements, there are several which aim to modulate glucose levels to modulate the insulin pathway, linked to the transformation of glucose into energy. There is a second strategy, still experimental, which aims to directly reduce protein production activity (the mTor pathway). And finally, there is also a third approach which focuses on the AMPK modulator pathway, through the stimulation of sirtuins.Calorie restriction is therefore one of the ways of activating sirtuins, particularly Sirt1, because it ‘shuts down’ cellular activity, especially when it is ‘over-revved’, i.e. over-stimulated by a high-calorie diet
Solongevity’s nutraceutical research has developed this latest strategy and devised a formula capable of stimulating the AMPK regulatory pathway through a very simple mechanism: make the cell believe it is in a condition of caloric restriction. In our case, we make the cell believe it is in a situation of caloric restriction in order to activate the minimisation of its operating regime (Sirtuin ⇒ AMPK ⇒ cellular metabolism reduction). 
SoLongevity’s research on sirtuins has led to the development of a nutraceutical that has been shown to balance oxidative stress and reduce inflammationThis mechanism entails a series of possible benefits that Solongevity is still partly studying: some have emerged from an observational point of view, i.e. from use in specific pre-pathological conditions, suggesting areas of application to be explored in order to understand the cause-effect relationships; others from the deduction that comes from the scientific literature. All the benefits to be declared will have to be measured in dedicated clinical studies.To date, the formula developed by Solongevity as a “mimetic of caloric restriction” has led to the development of a product which we have called, not by chance, CellFasting. This is not a meal replacement, nor a slimming product, but a nutraceutical which, together with a correct lifestyle and diet, helps to rebalance oxidative stress and reduce inflammatory parameters. Thanks to the combination of amino acids, polydatin and Acetylcysteine (NAC), CellFasting acts both as an anti-oxidant and by supporting energy metabolism, also reducing the sense of fatigue and tiredness.
SoLongevity’s research on sirtuins has led to the development of a nutraceutical that has been shown to balance oxidative stress and reduce inflammationThis mechanism entails a series of possible benefits that Solongevity is still partly studying: some have emerged from an observational point of view, i.e. from use in specific pre-pathological conditions, suggesting areas of application to be explored in order to understand the cause-effect relationships; others from the deduction that comes from the scientific literature. All the benefits to be declared will have to be measured in dedicated clinical studies.To date, the formula developed by Solongevity as a “mimetic of caloric restriction” has led to the development of a product which we have called, not by chance, CellFasting. This is not a meal replacement, nor a slimming product, but a nutraceutical which, together with a correct lifestyle and diet, helps to rebalance oxidative stress and reduce inflammatory parameters. Thanks to the combination of amino acids, polydatin and Acetylcysteine (NAC), CellFasting acts both as an anti-oxidant and by supporting energy metabolism, also reducing the sense of fatigue and tiredness.
