Between conferences, debates and well-being “raves” at Allianz MiCo, Milan explores the new frontiers of longevity medicine. A journey in four stages that will culminate in Rome to bring together science, ethics and social responsibility.
How is gut health connected to longevity? Interview with Francesca Jaboli, gastroenterologist at the SoLongevity Clinic in Milan
A study conducted on pairs of twins raises the role of genetics in determining lifespan: from less than 25% to over 50%. The comment of Alberto Beretta, President and Scientific Director of SoLongevity
A review of studies on the microbiota-gut-brain axis reveals how two-way communication between the digestive system and the central nervous system regulates sleep-wake cycles. Interview with Ginevra Pignata, neuroscientist and part of the medical team of the SoLongevity Clinic in Milan, who stresses the importance of a holistic approach
Longevity medicine involves an integrated approach to health, which also includes the urological and andrological consultation to ensure a high quality of life at any age
Although it has been shown that lifestyles play a leading role in combating disease and maintaining health, also from a longevity perspective, their integration into the healthcare system is a rare event. In this article we analyze the 6 lifestyle pillars of longevity and why it is important that they be prescribed by physicians as if they were drugs
The first check-up between ages 16 and 20 not only makes it possible to ascertain the health of the urogenital system, but is also a moment of education and prevention to remain healthy and “high-performing” for a long time
Menopause can have a very negative impact on careers and leads two women out of five to look for a new job. This is shown by a study by the Society for Women’s Health Research, which has created a road map to guide companies in adopting supportive policies
Precision Longevity™ is the philosophy that permeates all the activities of SoLongevity and the SoLongevity Clinic: combining the principles of precision medicine with those of longevity science for a tailor-made longevity project
SoLongevity offers a multidisciplinary program that starts from monitoring sleep and daily activities to develop a plan to improve the quality of rest. Here is how it works
Partly because of fluctuations in estrogen levels, menopause often brings with it a series of changes that concern not only the reproductive system, but also the central nervous system
On the occasion of the Milan Longevity Summit, from March 27 to 29, it will be possible to take part in workshops with the leading longevity experts. See you at the Teatro Franco Parenti in Milan
Within the major event, the days of March 27-28-29 are entirely organized by the SoLongevity Foundation at the Teatro Franco Parenti. With internationally renowned scientists, talks, round tables and over 40 workshops. From biological clocks that measure our true age to practical advice on nutrition, sleep, sport, dermatology
Brain Boost Program combines precision diagnostics and personalized medicine to improve cognitive function. Through a module-structured pathway, it acts on memory, attention, and executive skills, considering metabolic, neurological, and lifestyle factors. A comprehensive method to preserve and enhance cognitive performance over time
During autumn and winter, it is important to help the immune system maintain or regain its balance in order to fight more effectively the viruses responsible for colds, flu and Covid. Here is how
There is often confusion about these products and about what effect can be expected when taking them. Let’s clarify with the SoLongevity experts
Breathing can be trained through exercises to enhance health and longevity. Discover SoLongevity’s Breath Training Program
SoLongevity’s first clinic in Italy offers Precision Longevity™—a medical space designed to help you achieve healthy longevity goals and take a personalized approach to active prevention.
A 24-year study confirmed the inverse correlation between VO2 max and the risk of death from cardiovascular disease, cancer and other causes
At the congress of the Italian Society of Nutraceuticals (SINut), SoLongevity Nutraceuticals presented the first results of a new monitoring system that makes it possible to detect, from a drop of blood, a series of molecules involved in oxidative stress and in the energy metabolism of cells
SoLongevity launches Sport Longevity Hub: the most up-to-date scientific knowledge and expertise of Solongevity staff to check one’s starting health status and set up the most suitable training path for each person
Different dietary regimens have different effects on the gut microbiota: identifying the changes could make it possible to develop personalized dietary strategies to combat obesity and other metabolic diseases
Its discovery is the result of a study by the University of Padua. Its inhibition causes the onset of premature senescence
A large study conducted in the United Kingdom shows that individuals with a high genetic risk can extend their life expectancy by adopting a healthy lifestyle
BioClock SoLongevity is launched: the program that makes it possible to measure biological age and design a tailor-made program to turn back the hands of the biological clock while promoting the person’s health
If a centenarian says she drank a liter of wine every day of her life, does the rule apply that a liter of wine a day keeps the doctor away? Obviously not. It is called “survivorship bias”, as Bradley Elliott explains in The Conversation. Let us see what it is
Essential amino acids have many anti-aging properties. From SoLongevity research comes AminoAge Plus, a new nutraceutical designed to optimize them
Diet, physical activity, sleep, no smoking, and control of weight, cholesterol, blood sugar and blood pressure. These are the fundamental points according to the American Heart Association. Let us look at them in detail
The famous 10,000 steps a day needed to stay active and healthy have no real scientific basis. Here is what the scientific community has discovered so far about the importance of walking and how much we should do it
Thanks to its formula, it helps counteract the age-related reduction in peripheral vascularization and the hardening of the vessels
A new study conducted by Roberta Gualtierotti of the Policlinico di Milano suggests that these cellular power plants may not work as they should in people affected by the disease
From March 14 to 27, Milan will host the most important international longevity experts. Discover all the events and register for free
The combination of the two types of training has been shown to have positive effects on people with a mild form of cognitive decline
Some immune cells are activated in the muscles during physical activity to reduce inflammation. This could be a more general mechanism through which exercise helps promote our health
Researchers at Stanford University have developed a method to calculate the biological age of 11 body districts. This metabolomic clock could predict the development of dysfunction even before symptoms occur
According to a study published in Advanced Science, patients with mild to moderate forms of Covid-19 tend to recover faster when treated, in conjunction with antiviral therapy, with a combination of precursors of this molecule
An all-Italian research team has engineered a protein that promotes the exchange of information between neurons, making it activatable through the administration of rapamycin
Regular physical activity is essential for staying healthy, but, according to the results of a study published in Cell Metabolism, overdoing it may even become counterproductive
As we age, some cells of the immune system seem to lose their memory and revert to resembling those of infants. This makes them less effective in responding to previously encountered pathogens and could have implications in the development of new vaccines
Sounds composed of more powerful low frequencies seem to promote deep sleep and better cardiac function
Changes to the sleep-wake cycle can alter hormonal control over appetite and satiety, contributing to weight gain and increasing the risk of metabolic syndrome and diabetes
Five minutes of immersion in water at 20°C can cause a marked improvement in mood, and underlying these effects appear to be changes in functional connections between different brain areas
Dogs that eat only once a day seem to retain their cognitive abilities longer and generally have better health status
An increase in this amino acid in the blood, which may also be diet-dependent, increases the risk of several aging-related diseases
The reasons why women have a greater need for sleep than men lie in certain aspects of biology, but are also cultural and social
An advanced check-up of physical health status and cognitive performance, and risk factors for aging-related diseases. With an individualized program aimed at slowing biological age
Those taking higher doses of magnesium have, on average, a higher gray mass volume and fewer white matter lesions. However, further studies will be needed to confirm these results
Rapamycin, currently used as a post-transplant anti-rejection drug, appears to counteract the age-related reduction in histone expression. However, it can cause even serious side effects
A consensus document from the European Atherosclerosis Society gives physicians new guidance for testing and treating high blood Lp(a) concentrations
According to a study published in Scientific Reports, exercises involving breath control appear to have a positive impact on stress symptoms
In 2013, nine causes of aging had been explained. About ten years later, the number rises to 12
Fofo stands for “fear of finding out,” or fear of discovering that you suffer from a certain health problem. And the
consequence is a possible delay in treatment
Vascular problems and oxidative stress underlie the decline in cognitive performance associated with aging, and may contribute to the development of dementia and Alzheimer’s disease. But action can be taken to reduce risks
A genetic variant very common in centenarians appears to have the ability to restore the function of certain heart cells, improving overall organ function and turning back the hands of the biological clock
“Longevity proteins” are now the focus of numerous studies that are investigating their possible preventive role against neurodegenerative diseases
One in 4 Italians – and one in 2 among those over 50 – suffers from metabolic syndrome. Here’s how to diagnose it and how to intervene to reduce the risk of metabolic and vascular diseases
The idea that speeding up metabolism is helpful for losing weight fast is mostly a false myth. This is what the science shows us.
Excess homocysteine poses a health risk to the cardio- and cerebrovascular system because it stimulates the development of atherosclerosis, increasing the likelihood of stroke and heart attack. If action is taken early, by changing dietary habits and through supplements, levels can be normalized. With a double advantage
There are several methods for measuring oxidative stress. Knowing one’s “level” of oxidative stress can be useful in a preventive and healthy aging perspective
Telomere length is considered one of the hallmarks of aging, but new research is revealing that their “measurement” seems to be indicative more of health status than biological age. As Valentina Bollati, associate professor in the Department of Clinical and Community Sciences and the Epiget Lab at Milan State University, explains.
The biological age of an organism is a significant indicator of health status and susceptibility to illness. Individual organs and tissues may undergo different aging processes, but the real challenge is to define a biological clock that applies to the whole organism, and that translates into parameters that are easy to monitor and act upon.
Measuring chronic latent inflammation is not as simple as measuring acute inflammation associated with infection or disease. There are different types of tests and markers, with different sensitivities. Here is a brief guide to get your bearings
A study published in Cell suggests this. Researchers investigated the effects on the intestinal flora from sweeteners such as aspartame, saccharin, stevia or sucralose, and also analyzed their effects on blood glucose
Fermented foods are showing beneficial health properties. Here are a few, for every palate
Focusing only on treating chronic diseases when they occur is not a sustainable strategy. A change of perspective is needed: to invest, first, in healthy longevity. This is the philosophy of SoLongevity and other major players in Geroscience, who sign a manifesto of intent in Lancet Healthy Longevity
After menopause, women’s cardiovascular risk is quite comparable to that of men, yet it is underestimated even by health professionals
Many metabolic processes in the body produce free radicals that, under balanced conditions, are neutralized by antioxidants. Some external agents, however, as well as certain habits and diseases, increase the production of free radicals excessively, and generate a state of oxidative stress that is dangerous to health
SoLongevity Nutraceuticals is launching a new product, developed to regularize homocysteine and glutathione levels, promote blood vessel health, support cell energy metabolism, and contribute to cardio and neurovascular wellness
Roberto Pusinelli (40) and Violante Lama (42), competing with the Italian national team at the European Rowing Championships, participate in SoLongevity research to understand how to improve mitochondria efficiency and provide answers to combat Long Covid
Certain epigenetic mechanisms underlie the aging processes in many mammalian species, including humans. This is the basis of the watch of Steve Horvath, a pioneer in biological age research
Certain foods are associated with lower levels of inflammation, as measured by specific markers such as C Reactive Protein. Here are what these “shield” foods are for our health.
An American study measured the effects of urolithin A supplementation on muscle endurance and mitochondrial health. The results suggest that the substance aids a process called mitophagy, by which cells replace damaged mitochondria
A new mathematical model recalculates the theoretical maximum human lifespan, bringing it up to 150 years
There are many studies that are trying to define the optimal eating style to increase the number of years lived healthy. Much of the research focuses on intermittent fasting to determine what the best time window is. Exploring this world is a review by Italian scientist Valter Longo in Cell.
Resveratrol, polydatin, glutathione, and NAD+ are four of the so-called “longevity molecules” on which research has long focused. In a series of four articles we explain what they are and how they work.
SoLongevity research has developed a patented, clinically tested formula that can rebalance the Redox status and reduce inflammation, with the aim of preventing age-related decline in cognitive ability.
It is one of the most powerful natural antioxidants in our bodies. It plays a central role in tissue production and repair and defends us against numerous diseases. And it plays an important role in physiological processes related to aging.
Antioxidant and anti-inflammatory, resveratrol also appears to have antiviral action, limiting Sars-Cov-2 replication in nasal epithelium cells.
A diet rich in these foods increases the diversity of microorganisms in the gut microbiome and reduces inflammation.
NAD+ is a molecule involved in cellular metabolism and aging. As the age increases, its level actually decreases. But with appropriate supplementation, it can be restored.
Once seen only as helpful and protective, we now know that inflammation can contribute to the development of numerous diseases
Conducted by SoLongevity Research in collaboration with Sacco Hospital in Milan, the study will assess in more than 150 patients the efficacy of the nutraceutical on the redox state and on the symptoms of the disease, in particular on tiredness, brain fog and sleep quality.
High levels of antioxidants in the blood, in middle age and in older adults, are on average associated with a lower risk of later developing a form of dementia
PM2.5 particulate matter lowers the levels of a protein, sirtuin 2, which regulates important physiological processes underlying airway inflammation. This is revealed by a study that also identifies a potential therapeutic avenue
After GluRes, SoLongevity’s first patent, the GluReNAD nutraceutical formulation is also covered by a patent: by mimicking the effects of caloric restriction, it regulates metabolism and also helps reduce the sense of hunger thanks to the energy boost provided by the synergy of glutathione, resveratrol and NAD
One of the measures of biological age, telomere length, could predict the risk of developing severe forms of COVID-19. The finding applies above all to women over 65
The new coronavirus has been shown to have neurological and neuropsychiatric effects even in the long term. These mechanisms and the hypothesis that inflammation predisposes to the development of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, are being investigated.
According to a study conducted by IFOM in Milan and IGM-CNR in Pavia, the reason why older people are more susceptible to the SARS-CoV-2 virus could be linked to aging-related genetic damage
A polyphenol with antioxidant and anti-inflammatory properties, polydatin is a natural bioavailable molecule that also appears to reduce the infectivity of the coronavirus
A study conducted by SoLongevity Research and the University of Verona, published in eBioMedicine, reveals important new information on the serological response to vaccines. The presence of type M immunoglobulins is associated with a higher antibody level and a greater ability to neutralize the virus. And it suggests that the response to vaccination may depend on pre-existing immunity developed against other coronaviruses
Measuring one’s state of health against an ideal aging process allows us to understand how well we are able to preserve our physical and mental performance and how exposed we are to future risks of chronic diseases
What are amino acid supplements? What benefits do they have and how do they work? Who are they indicated for? Alessandro Orlandini, M.D., a pharmaceutical chemist and specialist in clinical biochemistry, now medical director of the Italian company Professional Dietetics, answers these questions.
When it comes to cardiovascular disease, the age of the immune system matters more than chronological age. Today the iAge “inflammatory clock” makes it possible to estimate it. How does it work?
Longevity genes can be activated with a specific mix of nutrients. This is what prompted SoLongevity research to develop a special formulation: a combination of amino acids, polydatin and NAC which, in a controlled clinical trial, proved effective in rebalancing oxidative stress and reducing inflammatory parameters.
A study published in Science identified four age-related phases of the metabolism: it is very fast in the first year of life, then slows down little by little until the age of 20, remains stable between 20 and 60, and only slows down again in later life.
They can leverage public trust and have a large presence throughout the country for easy access and proximity. This is why pharmacies are entitled to become more and more a point of reference for health: the first destination for primary care promotion
When it comes to cardiovascular disease, the age of our immune system matters more than age. Today, the iAge “inflammatory clock” allows us to estimate it. How does it work?
The third chapter of our guide is about the criteria for evaluating a food supplement. What “good” characteristics should it have? From certifications to bioavailability to the production chain.
In the second article of our guide to food supplementation, we offer a list of questions to figure out what you really need
The first of a series of articles to guide you into the world of dietary supplements. It starts from basic: what we should be aware of before approaching the food supplements’ shelf in pharmacies and herbalists, or in the supermarket
